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Mechanoresponsive Properties of the Periodontal Ligament

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dc.contributor.author차정열-
dc.date.accessioned2017-10-26T07:10:38Z-
dc.date.available2017-10-26T07:10:38Z-
dc.date.issued2016-
dc.identifier.issn0022-0345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151699-
dc.description.abstractThe periodontal ligament (PDL) functions as an enthesis, a connective tissue attachment that dissipates strains created by mechanical loading. Entheses are mechanoresponsive structures that rapidly adapt to changes in their mechanical loading; here we asked which features of the PDL are sensitive to such in vivo loading. We evaluated the PDL in 4 physiologically relevant mechanical environments, focusing on mitotic activity, cell density, collagen content, osteogenic protein expression, and organization of the tissue. In addition to examining PDLs that supported teeth under masticatory loading and eruptive forces, 2 additional mechanical conditions were created and analyzed: hypoloading and experimental tooth movement. Collectively, these data revealed that the adult PDL is a remarkably quiescent tissue and that only when it is subjected to increased loads--such as those associated with mastication, eruption, and orthodontic tooth movement-does the tissue increase its rate of cell proliferation and collagen production. These data have relevance in clinical scenarios where PDL acclimatization can be exploited to optimize tooth movement-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSage-
dc.relation.isPartOfJOURNAL OF DENTAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCollagen/metabolism-
dc.subject.MESHFinite Element Analysis-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMastication/physiology-
dc.subject.MESHMice-
dc.subject.MESHMicroscopy, Electron, Scanning-
dc.subject.MESHMitosis/physiology-
dc.subject.MESHPeriodontal Ligament/physiology*-
dc.subject.MESHStress, Mechanical-
dc.subject.MESHTooth Eruption/physiology-
dc.subject.MESHTooth Movement Techniques-
dc.titleMechanoresponsive Properties of the Periodontal Ligament-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Orthodontics-
dc.contributor.googleauthorL. Huang-
dc.contributor.googleauthorB. Liu-
dc.contributor.googleauthorJ.Y. Cha-
dc.contributor.googleauthorG. Yuan-
dc.contributor.googleauthorM. Kelly-
dc.contributor.googleauthorG. Singh-
dc.contributor.googleauthorS. Hyman-
dc.contributor.googleauthorJ.B. Brunski-
dc.contributor.googleauthorJ. Li-
dc.contributor.googleauthorJ.A. Helms-
dc.identifier.doi10.1177/0022034515626102-
dc.contributor.localIdA04006-
dc.relation.journalcodeJ01367-
dc.identifier.eissn1544-0591-
dc.identifier.pmid26767771-
dc.identifier.urlhttp://journals.sagepub.com/doi/abs/10.1177/0022034515626102-
dc.subject.keywordcollagen-
dc.subject.keywordenthesis-
dc.subject.keywordmechanical-
dc.subject.keywordorthodontic-
dc.subject.keywordproliferation-
dc.subject.keywordtooth movement-
dc.contributor.alternativeNameCha, Jung Yul-
dc.contributor.affiliatedAuthorCha, Jung Yul-
dc.citation.volume95-
dc.citation.number4-
dc.citation.startPage467-
dc.citation.endPage475-
dc.identifier.bibliographicCitationJOURNAL OF DENTAL RESEARCH, Vol.95(4) : 467-475, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid45713-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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