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Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer

DC FieldValueLanguage
dc.contributor.author박영진-
dc.contributor.author송호택-
dc.contributor.author송은혜-
dc.date.accessioned2017-10-26T07:07:05Z-
dc.date.available2017-10-26T07:07:05Z-
dc.date.issued2016-
dc.identifier.issn0927-7765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151622-
dc.description.abstractWe have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBreast Neoplasms/drug therapy*-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDoxorubicin/pharmacology-
dc.subject.MESHDoxorubicin/therapeutic use-
dc.subject.MESHDrug Delivery Systems-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKinetics-
dc.subject.MESHLuminescent Measurements-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHMicelles-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHPolyesters/chemistry*-
dc.subject.MESHPolyethylene Glycols/chemistry*-
dc.titleDevelopment of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorHo-Taek Song-
dc.contributor.googleauthorNgoc Ha Hoang-
dc.contributor.googleauthorJeong Min Yun-
dc.contributor.googleauthorYoung Jin Park-
dc.contributor.googleauthorEun Hye Song-
dc.contributor.googleauthorEun Seong Lee-
dc.contributor.googleauthorYu Seok Youn-
dc.contributor.googleauthorKyung Taek Oh-
dc.identifier.doi10.1016/j.colsurfb.2016.04.002-
dc.contributor.localIdA02080-
dc.contributor.localIdA02050-
dc.contributor.localIdA01572-
dc.relation.journalcodeJ00627-
dc.identifier.eissn1873-4367-
dc.identifier.pmid27070054-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0927776516302594-
dc.subject.keywordAnimal imaging-
dc.subject.keywordBiocompatibility-
dc.subject.keywordMetastasis-
dc.subject.keywordNanomedicine-
dc.subject.keywordTri-block copolymer-
dc.contributor.alternativeNamePark, Vivian Young Jean-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.alternativeNameSong, Eun Hye-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.contributor.affiliatedAuthorSong, Eun Hye-
dc.contributor.affiliatedAuthorPark, Vivian Youngjean-
dc.citation.volume144-
dc.citation.startPage73-
dc.citation.endPage80-
dc.identifier.bibliographicCitationCOLLOIDS AND SURFACES B-BIOINTERFACES, Vol.144 : 73-80, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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