Cited 18 times in
Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박영진 | - |
dc.contributor.author | 송호택 | - |
dc.contributor.author | 송은혜 | - |
dc.date.accessioned | 2017-10-26T07:07:05Z | - |
dc.date.available | 2017-10-26T07:07:05Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151622 | - |
dc.description.abstract | We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Breast Neoplasms/drug therapy* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Doxorubicin/pharmacology | - |
dc.subject.MESH | Doxorubicin/therapeutic use | - |
dc.subject.MESH | Drug Delivery Systems | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Luminescent Measurements | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Micelles | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Polyesters/chemistry* | - |
dc.subject.MESH | Polyethylene Glycols/chemistry* | - |
dc.title | Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Ho-Taek Song | - |
dc.contributor.googleauthor | Ngoc Ha Hoang | - |
dc.contributor.googleauthor | Jeong Min Yun | - |
dc.contributor.googleauthor | Young Jin Park | - |
dc.contributor.googleauthor | Eun Hye Song | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.contributor.googleauthor | Yu Seok Youn | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.04.002 | - |
dc.contributor.localId | A02080 | - |
dc.contributor.localId | A02050 | - |
dc.contributor.localId | A01572 | - |
dc.relation.journalcode | J00627 | - |
dc.identifier.eissn | 1873-4367 | - |
dc.identifier.pmid | 27070054 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0927776516302594 | - |
dc.subject.keyword | Animal imaging | - |
dc.subject.keyword | Biocompatibility | - |
dc.subject.keyword | Metastasis | - |
dc.subject.keyword | Nanomedicine | - |
dc.subject.keyword | Tri-block copolymer | - |
dc.contributor.alternativeName | Park, Vivian Young Jean | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.alternativeName | Song, Eun Hye | - |
dc.contributor.affiliatedAuthor | Song, Ho Taek | - |
dc.contributor.affiliatedAuthor | Song, Eun Hye | - |
dc.contributor.affiliatedAuthor | Park, Vivian Youngjean | - |
dc.citation.volume | 144 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.144 : 73-80, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45258 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.