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β2-아드레날린성 수용체 유전자 다형성이원발성 고혈압에 미치는 영향

Other Titles
 The Effects of the β2-Adrenergic Receptor Gene Polymorphism on theRisk of Essential Hypertension 
Authors
 정재헌  ;  민필기  ;  박현영  ;  황기철  ;  조은영  ;  정광회  ;  장양수 
Citation
 KOREAN CIRCULATION JOURNAL, Vol.35(10) : 753-758, 2005 
Journal Title
 KOREAN CIRCULATION JOURNAL 
ISSN
 1738-5520 
Issue Date
2005
Abstract
Background and Objectives:Considering the physiological importance of the β2-adrenergic receptor (ADRB2) gene, "functional" molecular variations of the gene might cause attenuated vasodilatation, leading to increased total peripheral resistance and; hence, ultimately result in hypertension. Significant evidence has been provided for the pathophysiological involvement of the β2-adrenergic receptor (ADRB2) in hypertension. The genetic variation of the ADRB2 gene, to see if there might be any relationship to essential hypertension, was investigated. Subjects and Methods:One ADRB2 gene polymorphism, Arg16Gly (Arg→Gly variant), was investigated in this study. The genotypes of Arg16Gly in 318 hypertensive patients and 309 normotensive subjects were analyzed. Results:No significant differences were found in the allele and genotype frequencies between patients with hypertension and normotensive subjects. There was no association of the ADRB2 polymorphism (Arg16Gly) with hypertension or the other phenotypes measured in our study populations. Conclusion:Our data suggest that ADRB2 Arg16Gly polymorphisms are unlikely to confer the genetic susceptibility for hypertension in the Korean population. However, further investigation is warranted to clarify the relevance of ADRB2 polymorphisms in blood pressure regulation.
Files in This Item:
T200501460.pdf Download
DOI
OAK-2005-06283
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyun Young(박현영)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Kwang Hoe(정광회)
Cho, Eun Young(조은영)
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151531
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