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β2-아드레날린성 수용체 유전자 다형성이원발성 고혈압에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 박현영 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 정광회 | - |
dc.contributor.author | 조은영 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2017-10-26T06:57:06Z | - |
dc.date.available | 2017-10-26T06:57:06Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151531 | - |
dc.description.abstract | Background and Objectives:Considering the physiological importance of the β2-adrenergic receptor (ADRB2) gene, "functional" molecular variations of the gene might cause attenuated vasodilatation, leading to increased total peripheral resistance and; hence, ultimately result in hypertension. Significant evidence has been provided for the pathophysiological involvement of the β2-adrenergic receptor (ADRB2) in hypertension. The genetic variation of the ADRB2 gene, to see if there might be any relationship to essential hypertension, was investigated. Subjects and Methods:One ADRB2 gene polymorphism, Arg16Gly (Arg→Gly variant), was investigated in this study. The genotypes of Arg16Gly in 318 hypertensive patients and 309 normotensive subjects were analyzed. Results:No significant differences were found in the allele and genotype frequencies between patients with hypertension and normotensive subjects. There was no association of the ADRB2 polymorphism (Arg16Gly) with hypertension or the other phenotypes measured in our study populations. Conclusion:Our data suggest that ADRB2 Arg16Gly polymorphisms are unlikely to confer the genetic susceptibility for hypertension in the Korean population. However, further investigation is warranted to clarify the relevance of ADRB2 polymorphisms in blood pressure regulation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | β2-아드레날린성 수용체 유전자 다형성이원발성 고혈압에 미치는 영향 | - |
dc.title.alternative | The Effects of the β2-Adrenergic Receptor Gene Polymorphism on theRisk of Essential Hypertension | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | Research Institutes (연구소) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | Research Institutes (연구소) | - |
dc.contributor.college | Research Institutes (연구소) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | 정재헌 | - |
dc.contributor.googleauthor | 민필기 | - |
dc.contributor.googleauthor | 박현영 | - |
dc.contributor.googleauthor | 황기철 | - |
dc.contributor.googleauthor | 조은영 | - |
dc.contributor.googleauthor | 정광회 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.identifier.doi | OAK-2005-06283 | - |
dc.contributor.localId | A01742 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03576 | - |
dc.contributor.localId | A03884 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.relation.journalsince | 2005~ | - |
dc.relation.journalbefore | ~2004 Korean Circulation Journal (순환기) | - |
dc.contributor.alternativeName | Park, Hyun Young | - |
dc.contributor.alternativeName | Park, Hyun Young | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Chung, Kwang Hoe | - |
dc.contributor.alternativeName | Cho, Eun Young | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | 박현영 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 753 | - |
dc.citation.endPage | 758 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.35(10) : 753-758, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44684 | - |
dc.type.rims | ART | - |
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