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Gadobenate Dimeglumine as an Itrabiliary Contrast Agent : Comparison with Mangafodipir Trisodium with Respect to Non-dilatedBiliary Tree Depiction

 Joon Seok Lim  ;  Myeong-Jin Kim  ;  Yong Yun Jung  ;  Ki Whang Kim 
 KOREAN JOURNAL OF RADIOLOGY, Vol.6(4) : 229-234, 2005 
Journal Title
Issue Date
Adult ; Aged ; Bile Ducts/anatomy & histology* ; Common Bile Duct/anatomy & histology ; Contrast Media* ; Edetic Acid/analogs & derivatives* ; Feasibility Studies ; Female ; Hepatic Duct, Common/anatomy & histology ; Humans ; Magnetic Resonance Imaging* ; Male ; Meglumine/analogs & derivatives* ; Middle Aged ; Organometallic Compounds* ; Pyridoxal Phosphate/analogs & derivatives*
Magnetic resonance (MR), contrast media ; Bile duct radiography, technology ; Bile ducts, anatomy
OBJECTIVE: To compare the efficacy of Mangafodipir trisodium (Mn-DPDP)-enhanced MR cholangiogrphy (MRC) and Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRC in visualizing a non-dilated biliary system. MATERIALS AND METHODS: Eighty-eight healthy liver donor candidates underwent contrast-enhanced T1-weighted MRC. Mn-DPDP and Gd-BOPTA was used in 36 and 52 patients, respectively. Two radiologists reviewed the MR images and rated the visualization of the common duct, the right and left hepatic ducts, and the second-order branches using a 4-point scale. The contrast-to-noise ratio (CNR) of the common duct to the liver in the two groups was also compared. RESULTS: Mn-DPDP MRC and Gd-BOPTA MRC both showed similar visualization grades in the common duct (p=.380, Mann-Whitney U test). In the case of the proximal bile ducts, the median visualization grade was significantly higher with Gd-BOPTA MRC than with Mn-DPDP MRC (right hepatic duct: p=0.016, left hepatic duct: p=0.014, right secondary order branches: p=0.006, left secondary order branches, p=0.003). The common duct-to-liver CNR of the Gd-BOPTA MRC group was significantly higher (38.90+/-24.50) than that of the Mn-DPDP MRC group (24.14+/-17.98) (p=.003, Student's t test). CONCLUSION: Gd-BOPTA, as a biliary contrast agent, is a potential substitute for Mn-DPDP.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
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