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A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis

 Hee Jung Yoon  ;  Jun Yong Choi  ;  Chang Oh Kim  ;  June Myung Kim  ;  Young Goo Song 
 Yonsei Medical Journal, Vol.46(4) : 496-502, 2005 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Cohort Studies ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology* ; Female ; Humans ; Male ; Methicillin Resistance* ; Middle Aged ; Retrospective Studies ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology* ; Staphylococcus aureus/drug effects*
Staphylococcus aureus ; bacteremia ; endocarditis
Our objective was to assess the clinical factors that would reliably distinguish methicillin-resistant S. aureus (MRSA) from methicillin-susceptible S. aureus (MSSA) endocarditis. A retrospective cohort study of clinical features and mortality in patients with MRSA and MSSA endocarditis between March 1986 and March 2004 was performed in a 750-bed, tertiary care teaching hospital. A total of 32 patients (10 MRSA [31.3%] vs 22 MSSA [68.7%]) were evaluated. Their mean age and sex ratio (male/female) were as follows: 30.8 ± 16.0 vs 24.4±19.6 years old and 6/4 vs 13/9, for MRSA and MSSA infective endocarditis (IE), respectively. Univariate and multivariate analyses revealed that persistent bacteremia was significantly more prevalent in MRSA IE (OR, 10.0 [1.480-67.552]; p, 0.018). There was a higher mortality trend for MRSA IE (50.0%) than for MSSA IE (9.1%) (p=0.019). However, persistent bacteremia was not associated with higher mortality (p>0.05). These results indicate that if persistent bacteremia is documented, the likelihood of MRSA endocarditis should be viewed as high, and the patient's antistaphylococcal therapy should be prolonged and/or changed to a more "potent" regimen.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Yoon, Hee Jung(윤희정)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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