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인간 배자에서 코의 초기발생 : 입체현미경 및 조직학적 분석

Other Titles
 Early Development of the Nose in Human Embryo:A Stereomicroscopic and Histologic Analysis 
 김창훈  ;  유종범  ;  신우철  ;  김민범  ;  박형우  ;  윤주헌 
 Korean Journal of Otolaryngology (대한이비인후과학회지), Vol.48(3) : 338-346, 2005 
Journal Title
 Korean Journal of Otolaryngology (대한이비인후과학회지) 
Issue Date
Embryonic Development/physiology* ; Gestational Age ; Humans ; Microscopy/methods ; Nose/embryology* ; Nose/pathology
Human embryo ; nose ; early development ; Carnegie stage
Background and Objectives: We aimed to analyze the morphologic features of the nose in the human embryo from 4th to 8th developmental weeks according to the Carnegie stage. Materials and Method: A total of 27 cases of embryos, ranging from Carnegie stage of 13 to 23, were analyzed. The external morphology was observed with a stereomicroscope, photographed and analyzed. The histologic features were observed with a light microscope in the horizontally-transected specimens stained with hematoxylin-eosin staining. Results: The nasal placode was observed at the stage 13, and it became flat or even concave at the stage 14. At the stage 15, the nasal pit was formed. At the stage 16, the nasal sac and nasal fin were observed. At the stage 17, the oronasal membrane was formed by thinning of the nasal fin. At the stage 18, the primitive choana was established by rupture of the oronasal membrane. At the stage 19, the lateral palatine process projected vertically below the level of the tongue. The cartilaginous nasal capsule was formed at the stage 20. At the stage 21, the olfactory area was localized to the upper portion of the lateral nasal wall and the nasal septum. At the stage 22, the lateral palatine process developed in a somewhat horizontal orientation. At the stage 23, the premaxilla and primitive choana were formed. Conclusion: The development of the nose is most active from the Carnegie stage of 13 to 19, which corresponds to the end of the 4th embryonic week to the end of the 7th week. Thus, this period is considered to be the most important period in human nasal embryonic development.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
Yoon, Joo Heon(윤주헌)
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