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저산소 및 재산소화가 배양된 태아 섬유아세포에 미치는 영향

Other Titles
 Effect of Hypoxia and Reoxygenation on Cultured Human Dermal Fetal Fibroblast 
 박병윤  ;  최종우  ;  곽혁준  ;  이원재  ;  나동균  ;  곽현준 
 Journal of the Korean Society of Plastic and Reconstructive Surgery (대한성형외과학회지), Vol.32(3) : 347-356, 2005 
Journal Title
 Journal of the Korean Society of Plastic and Reconstructive Surgery (대한성형외과학회지) 
Issue Date
Hypoxi ; Re-oxygenation ; Fetal fibroblast ; Collagen ; TGF-β ; VEGF ; TNF- α
Hypoxi ; Re-oxygenation ; Fetal fibroblast ; Collagen ; TGF-β ; VEGF ; TNF- α
The wound healing process in fetus is quite different form that of adult. Regeneration plays an important role and scarless wound healing is possible in early gestational fetal period. Recently, the various effects of the hypoxia and reoxygenation in the wound healing process have been investigated by many researchers. The hypoxic state is known to alter protein synthesis and gene expression of TGF-β, VEGF. The authors hypothesize there may be differences between fetal and adult fibroblast and this difference may play a possible role in the mechanism of scarless fetal wound healing. In this study, we investigated the growth of fibroblast, the amount of collagen deposition, the amount of protein synthesis and gene expression in TGF-β(transforming growth factor-β), VEGF(vascular endothelial growth factor) under the various hypoxic and reoxygenation conditions. Through these processes, we tried to determine the relationships between scarless fetal wound healing and hypoxic condition. In control group, fetal and adult fibroblasts were cultured under normoxic condition. The experimental groups were allocated into four different groups. The differences in TGF-beta, VEGF under 24, 48, 72 hours were statistically investigated. Compared to adult fibroblast group, there was a statistically significant increase (p<0.01) in the rates of protein synthesis in TGF-beta and VEGF of fetal fibroblast. In this study, these results may reflect the possibility that fetal fibroblast are more susceptible to change in oxygen and has a superior rate of angiogenesis through increased VEGF expression. The possible superiority of angiogenesis in fetal fibroblast may play an important role in scarless wound healing.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Rah, Dong Kyun(나동균)
Park, Beyoung Yun(박병윤)
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
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