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간세포암의 진단과 재발판정에서 PIVKA-II의 유용성

Other Titles
 Usefulness of PIVKA-II for diagnosis and evaluation of recurrence of hepatocellular carcinoma 
 김도영  ;  백용한  ;  한광협  ;  안상훈  ;  김경규  ;  김자경  ;  심명기  ;  이관식  ;  전재윤  ;  문영명 
 Korean Journal of Medicine (대한내과학회지), Vol.69(1) : 39-45, 2005 
Journal Title
Korean Journal of Medicine(대한내과학회지)
Issue Date
PIVKA-II ; Carcinoma, Hepatocellular
PIVKA-II ; Carcinoma, Hepatocellular
Backgroud: Although alpha-fetoprotein (AFP) is most widely used tumor marker for hepatocellular carcinoma (HCC), the sensitivity is about 60~70% in advanced HCC. Furthermore, the specificity of AFP is relatively low. The aim of this study was to evaluate the usefulness of prothrombin-induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of HCC, and of recurrence after curative surgical resection.
Methods: Between April 2001 and March 2004, a total of 245 patients with pathologically confirmed HCC and a total of 267 patients with non-HCC, chronic liver diseases were enrolled.
Results: With cutoff-value 20 ng/mL for AFP and 40 mAU/mL for PIVKA-II, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively. The specificity of them was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. For HCC 3≤cm, the sensitivity of AFP, PIVKA-II and AFP+PIVKA-II was 42.5% (31/73), 50.7% (37/73), and 68.5% (50/73), respectively. Among the 42 patients with AFP less than 20 ng/mL, whose tumor size was equal to or less than 3 cm, PIVKA-II showed positivity in 19 patients (45.2%). Recurrent HCC developed after curative surgical resection in 27 patients, and the sensitivity of PIVKA-II was 74.1% (20/27). On the contrary, the sensitivity of AFP was 40.7% (16/27).
Conclusion : PIVKA-II is a useful tumor marker for HCC, especially in small sized tumor and HCC without AFP elevation. Furthermore, serial measurement of PIVKA-II after surgical resection might be an early indicator for tumor recurrence
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Kyu(김경규)
Kim, Do Young(김도영)
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Paik, Yong Han(백용한)
Sim, Myoung Ki(심명기)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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