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간세포암의 진단과 재발판정에서 PIVKA-II의 유용성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경규 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김자경 | - |
dc.contributor.author | 백용한 | - |
dc.contributor.author | 심명기 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이관식 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2017-10-26T06:38:24Z | - |
dc.date.available | 2017-10-26T06:38:24Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1226-329X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151114 | - |
dc.description.abstract | Backgroud: Although alpha-fetoprotein (AFP) is most widely used tumor marker for hepatocellular carcinoma (HCC), the sensitivity is about 60~70% in advanced HCC. Furthermore, the specificity of AFP is relatively low. The aim of this study was to evaluate the usefulness of prothrombin-induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of HCC, and of recurrence after curative surgical resection. Methods: Between April 2001 and March 2004, a total of 245 patients with pathologically confirmed HCC and a total of 267 patients with non-HCC, chronic liver diseases were enrolled. Results: With cutoff-value 20 ng/mL for AFP and 40 mAU/mL for PIVKA-II, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively. The specificity of them was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. For HCC 3≤cm, the sensitivity of AFP, PIVKA-II and AFP+PIVKA-II was 42.5% (31/73), 50.7% (37/73), and 68.5% (50/73), respectively. Among the 42 patients with AFP less than 20 ng/mL, whose tumor size was equal to or less than 3 cm, PIVKA-II showed positivity in 19 patients (45.2%). Recurrent HCC developed after curative surgical resection in 27 patients, and the sensitivity of PIVKA-II was 74.1% (20/27). On the contrary, the sensitivity of AFP was 40.7% (16/27). Conclusion : PIVKA-II is a useful tumor marker for HCC, especially in small sized tumor and HCC without AFP elevation. Furthermore, serial measurement of PIVKA-II after surgical resection might be an early indicator for tumor recurrence | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한내과학회 | - |
dc.relation.isPartOf | Korean Journal of Medicine (대한내과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | PIVKA-II | - |
dc.subject.MESH | Carcinoma, Hepatocellular | - |
dc.title | 간세포암의 진단과 재발판정에서 PIVKA-II의 유용성 | - |
dc.title.alternative | Usefulness of PIVKA-II for diagnosis and evaluation of recurrence of hepatocellular carcinoma | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 김도영 | - |
dc.contributor.googleauthor | 백용한 | - |
dc.contributor.googleauthor | 한광협 | - |
dc.contributor.googleauthor | 안상훈 | - |
dc.contributor.googleauthor | 김경규 | - |
dc.contributor.googleauthor | 김자경 | - |
dc.contributor.googleauthor | 심명기 | - |
dc.contributor.googleauthor | 이관식 | - |
dc.contributor.googleauthor | 전재윤 | - |
dc.contributor.googleauthor | 문영명 | - |
dc.identifier.doi | OAK-2005-04762 | - |
dc.contributor.localId | A00291 | - |
dc.contributor.localId | A00385 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A01829 | - |
dc.contributor.localId | A02192 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J02060 | - |
dc.relation.journalsince | 1993~2005 | - |
dc.relation.journalafter | 2006~ Korean Journal of Medicine | - |
dc.subject.keyword | PIVKA-II | - |
dc.subject.keyword | Carcinoma, Hepatocellular | - |
dc.contributor.alternativeName | Kim, Kyung Kyu | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Paik, Yong Han | - |
dc.contributor.alternativeName | Sim, Myoung Ki | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.citation.volume | 69 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 45 | - |
dc.identifier.bibliographicCitation | Korean Journal of Medicine (대한내과학회지), Vol.69(1) : 39-45, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43456 | - |
dc.type.rims | ART | - |
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