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Interindividual reproducibility of glutamate quantification using 1.5-T proton magnetic resonance spectroscopy

Authors
 Dong-Pyo Jang  ;  Jong-Min Lee  ;  Eun Lee  ;  Sangjin Park  ;  Jae-Jin Kim  ;  Kee Namkoong  ;  Kang-Jun Yoon  ;  In-Young Kim  ;  Sun I. Kim 
Citation
 MAGNETIC RESONANCE IN MEDICINE, Vol.53(3) : 708-712, 2005 
Journal Title
 MAGNETIC RESONANCE IN MEDICINE 
ISSN
 0740-3194 
Issue Date
2005
MeSH
Adult ; Brain/metabolism* ; Brain Chemistry ; Glutamic Acid/metabolism* ; Humans ; Magnetic Resonance Spectroscopy/methods* ; Male ; Middle Aged ; Phantoms, Imaging ; Reproducibility of Results
Keywords
glutamate ; reproducibility ; 1H MRS ; effective echo time ; quantification
Abstract
The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest = 4 cm(3)). The average Cramer-Rao lower bounds for glutamate quantification using LCModel was lowest in two experiments when TE = 40 ms.Twenty-one subjects participated in experiments that measured interindividual reproducibility of glutamate quantification. Spectra were acquired with TR = 6000 ms and TE = 40 ms. Results showed that the coefficients of variance were 11.0 and 13.1% in the anterior cingulate cortex and insula, respectively. This suggests that glutamate can be reproducibly measured from 1.5-T (1)H MRS with long TR, effective TE, and the LCModel.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mrm.20387/abstract
DOI
10.1002/mrm.20387
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151065
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