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실내 환경에서 집먼지 내독소에 대한노출과 알레르기 감작과의 관계

Other Titles
 House Dust Endotoxin Exposure and Allergic Sensitization inKorean Home Living Conditions 
Authors
 권병철  ;  송태원  ;  최성연  ;  신윤호  ;  이경은  ;  손명현  ;  김규언  ;  박중원  ;  홍천수 
Citation
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.15(1) : 18-25, 2005 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
ISSN
 1225-679X 
Issue Date
2005
Abstract
Purpose: Household endotoxin exposure in allergy and asthma has been gaining attention for its dual potential to exacerbate these conditions in individuals with established disease and to abrogate atopy before disease onset. The aim of this work was to analyze associations between current exposure to bacterial endotoxin in house dust and allergic sensitization in adults with asthma. Methods: From the homes of 52 adults with asthma and 28 normal controls, house dust endotoxin(detected with a Limulus Amebocyte Lysate QCL-1000) and house dust mite allergens(Der f 1 and Der p 1) were quantified. Allergen sensitization was measured by skin prick test. Results: The endotoxin levels from mattresses were lower in the home of adults with asthma than in that of normal controls. The endotoxin levels from mattresses detected in the home of adults with asthma were positively correlated with Der p 1 levels and wheal size to housedust mite allergens on skin prick tests. Furthermore, the endotoxin levels in living room floor dust were positively correlated with Der f 1 levels, but didn’t relate with wheal size to house dust mite allergens. Conclusion: Our results indicate that current exposure to house dust endotoxin might be positively associated with allergic sensitization in adults with asthma.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Song, Tae Won(송태원)
Lee, Kyung Eun(이경은)
Hong, Chein Soo(홍천수)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150570
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