연령관련황반변성에 의한 맥락막하신생혈관에서 광역학치료와 유리체강내 스테로이드주입술의 치료효과

Abstract

Purpose: To evaluate the safety and visual outcome of intravitreal triamcinolone acetonide combined with photodynamic therapy for subfoveal choroidal neovascularization in patients with age-related macular degeneration.

Methods: We evaluated 32 eyes of 32 patients with choroidal neovascularization due to age-related maculardegeneration. The study group received photodynamic therapy and intravitreal triamcinolone acetonide(combined group), while the control group received photodynamic therapy only (PDT group).

Results: Three months after treatment, no difference was detected between the two groups in visual acuity changes (p>0.05), but the leakage in fluorescein angiography and macular edema in optical coherent tomography decreased (p<0.05) in the combined group. The retreatment rate in the combined group (6.0%) after 3 months was lower than that of the PDT group (53.3%).

Conclusions: Photodynamic therapy with intravitreal triamcinolone acetonide to choroidal neovascularization reduced the retreatment rate at 3 months significantly. These results may have been be due to the short-term anti-inflammatory effect of steroids.