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고혈압 환자에서 C반응단백과 상완-발목 맥파 속도의 관계

Other Titles
 The Relationship between C-reactive Protein and Brachial-ankle Pulse Wave Velocity in Hypertention Patients 
Authors
 이지원  ;  김상환  ;  임지애  ;  이덕철 
Citation
 Korean Journal of Clinical Geriatrics (임상노인의학회지), Vol.5(4) : 474-483, 2004 
Journal Title
 Korean Journal of Clinical Geriatrics (임상노인의학회지) 
ISSN
 1229-6538 
Issue Date
2004
Keywords
Brachial-ankle pulse wave velocity ; C-reactive protein ; Inflammation
Abstract
Background: C-reactive protein (CRP) levels predict outcome in hypertensive patients with atherosclerosis. Arterial stiffness also independently predicts all-cause and cardiovascular mortality and may be involved in process of atherosclerosis. The aim of this study was to investigate the relationship between brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, and inflammation. Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were assessed in 63 individuals. Age, gender, smoking, pulse pressure, body mass index (BMI) ,fasting blood glucose, lipid parameters, CRP, lipoprotein (a) were measured. Pearson’s correlation analysis and multiple regression analysis were conducted to identify the relationship betweeen baPWV and parameters. Results: Brachial-ankle pulse wave velocity (baPWV) was correlated significantly with age (r=0.497; P<0.001), pulse pressure (r=0.454; P=0.001), high density lipoprotein (r=0.286; P=0.023), and CRP (r=0.288; P=0.022). In multiple regression models, after adjustment for age, gender, BMI, heart rate, pulse pressure, high density lipoprotein, and hypertension medication, baPWV was independently correlated with CRP (adjusted R2=0.417, P=0.034). Conclusion: Brachial-ankle pulse wave velocity had a significant relation with levels of CRP in patients with hypertension, suggesting that inflammation may be involved in arterial stiffening.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149923
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