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한국인 폐경 후 여성에서 비타민 D 수용체 유전자 프로모터의 Cdx-2 다형성이 골밀도에 미치는 영향

Other Titles
 The Effects of Cdx-2 Polymorphism in the Promoter Region of the Vitamin D Receptor Gene on Bone Mineral Density in Postmenopausal Korean Women 
Authors
 김세화  ;  이유미  ;  박소영  ;  김똘미  ;  이시훈  ;  안철우  ;  차봉수  ;  김경래  ;  이현철  ;  임승길 
Citation
 Journal of Korean Society of Osteoporosis (대한골다공증학회지), Vol.3(1) : 54-61, 2005 
Journal Title
 Journal of Korean Society of Osteoporosis (대한골다공증학회지) 
ISSN
 1738-0359 
Issue Date
2005
MeSH
Cdx-2 ; Cdx-2 polymorphism ; Vitamin D receptor gene ; Bone mineral density
Keywords
Cdx-2 ; Cdx-2 polymorphism ; Vitamin D receptor gene ; Bone mineral density
Abstract
Objectives: The intestine-specific transcription factor Cdx-2 played an important role in the transcription of the human vitamin D receptor(VDR) gene. The objective of this study was to investigate the relationship between the Cdx-2 polymorphism in the promoter region of the vitamin D receptor gene and the bone mineral density(BMD) in postmenopausal Korean women. Methods: We enrolled 150 healthy postmenopausal women. The bone mineral density at the lumbar spine and proximal femur were measured by dual energy X-ray absorptiometry. The polymorphism was analyzed in the core sequence 5'-ATAAAAACTTAT-3' in the Cdx-2 binding site in the VDR gene promoter(Cdx-2 polymorphism). Results: In 150 postmenopausal women, 30 were genotype Cdx-A(adenine at -3731 nucleotides relative to the transcription start site of human VDR gene 5'-ATAAAAACTTAT-3'), 54 were genotype Cdx-G(guanine at -3731 nucleotides, 5'-GTAAAAACTTAT-3'), and 66 were genotype Cdx-AG(heterozygote). A significant intergroup difference in BMD was not found at the lumbar spine and proximal femur among the different genotypes(p=ns). There was no difference in distribution of the Cdx-2 genotype between the osteoporosis and control group(՗2=1.76, P=0.415). Even in the individuals with a low calcium intake(daily calcium intake less than 400mg), there was no association of Cdx-2 genotype with lumbar spine BMD or proximal femur BMD. Conclusion: These results showed that there was no significant effect of Cdx-2 polymorphism in the promoter region of the vitamin D receptor gene on BMD in postmenopausal Korean women.
Files in This Item:
T200501653.pdf Download
DOI
OAK-2005-06747
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149866
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