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한국인 폐경 후 여성에서 비타민 D 수용체 유전자 프로모터의 Cdx-2 다형성이 골밀도에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경래 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2017-09-29T06:30:19Z | - |
dc.date.available | 2017-09-29T06:30:19Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-0359 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149866 | - |
dc.description.abstract | Objectives: The intestine-specific transcription factor Cdx-2 played an important role in the transcription of the human vitamin D receptor(VDR) gene. The objective of this study was to investigate the relationship between the Cdx-2 polymorphism in the promoter region of the vitamin D receptor gene and the bone mineral density(BMD) in postmenopausal Korean women. Methods: We enrolled 150 healthy postmenopausal women. The bone mineral density at the lumbar spine and proximal femur were measured by dual energy X-ray absorptiometry. The polymorphism was analyzed in the core sequence 5'-ATAAAAACTTAT-3' in the Cdx-2 binding site in the VDR gene promoter(Cdx-2 polymorphism). Results: In 150 postmenopausal women, 30 were genotype Cdx-A(adenine at -3731 nucleotides relative to the transcription start site of human VDR gene 5'-ATAAAAACTTAT-3'), 54 were genotype Cdx-G(guanine at -3731 nucleotides, 5'-GTAAAAACTTAT-3'), and 66 were genotype Cdx-AG(heterozygote). A significant intergroup difference in BMD was not found at the lumbar spine and proximal femur among the different genotypes(p=ns). There was no difference in distribution of the Cdx-2 genotype between the osteoporosis and control group(2=1.76, P=0.415). Even in the individuals with a low calcium intake(daily calcium intake less than 400mg), there was no association of Cdx-2 genotype with lumbar spine BMD or proximal femur BMD. Conclusion: These results showed that there was no significant effect of Cdx-2 polymorphism in the promoter region of the vitamin D receptor gene on BMD in postmenopausal Korean women. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한골다공증학회 | - |
dc.relation.isPartOf | Journal of Korean Society of Osteoporosis (대한골다공증학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cdx-2 | - |
dc.subject.MESH | Cdx-2 polymorphism | - |
dc.subject.MESH | Vitamin D receptor gene | - |
dc.subject.MESH | Bone mineral density | - |
dc.title | 한국인 폐경 후 여성에서 비타민 D 수용체 유전자 프로모터의 Cdx-2 다형성이 골밀도에 미치는 영향 | - |
dc.title.alternative | The Effects of Cdx-2 Polymorphism in the Promoter Region of the Vitamin D Receptor Gene on Bone Mineral Density in Postmenopausal Korean Women | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 김세화 | - |
dc.contributor.googleauthor | 이유미 | - |
dc.contributor.googleauthor | 박소영 | - |
dc.contributor.googleauthor | 김똘미 | - |
dc.contributor.googleauthor | 이시훈 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.identifier.doi | OAK-2005-06747 | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J01547 | - |
dc.relation.journalsince | 2003~2010 | - |
dc.relation.journalafter | 2010~ Osteoporosis | - |
dc.subject.keyword | Cdx-2 | - |
dc.subject.keyword | Cdx-2 polymorphism | - |
dc.subject.keyword | Vitamin D receptor gene | - |
dc.subject.keyword | Bone mineral density | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.citation.volume | 3 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 61 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Osteoporosis (대한골다공증학회지), Vol.3(1) : 54-61, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 41958 | - |
dc.type.rims | ART | - |
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