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Tumor mesenchymal stem-like cell as a prognostic marker in primary glioblastoma

Authors
 윤선진 
Issue Date
2016
Description
의과대학/석사
Abstract
The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined. This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014. Survival, extent of resection, molecular markers and tMSLC culture results were statistically evaluated. Median overall survival was 18.6 months, 15.0 months in tMSLC-positive and 29.5 months in tMSLC-negative patients (P=0.014). Multivariate cox regression model showed isolation of tMSLC (OR=2.5, 95% CI=1.1~5.6, P=0.021) showed poor outcome while larger extent of resection (OR=0.5, 95% CI=0.2~0.8, P=0.011) have association with better outcome. The presence of tMSLCs isolated from the specimen of pGBM is associated with the survival of patient.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/148915
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