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Differentiation between focal malignant-replacing lesions and benign red marrow deposition of the spine with T2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence

Other Titles
 Three-echo VIBE Dixon 자기공명영상을 이용한 척추의 골수를 대체하는 악성 병변과 양성 적색골수 침착의 감별 
Authors
 김용표 
Department
 Dept. of Radiology (영상의학교실) 
Issue Date
2015
Description
의과대학/석사
Abstract
Objective: To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae.



Materials and Methods: We assessed 32 lesions from 32 patients who underwent magnetic resonance imaging after being referred for assessment of a known or possible vertebral marrow abnormality. The lesions were divided into 21 malignant marrow-replacing lesions and 11 benign red marrow depositions. Three sequences for the parameter measurements were obtained by using a 1.5-T MR imaging scanner as follows: three-echo VIBE Dixon sequence for FF; conventional T1-weighted imaging for the lesion-disc ratio (LDR); pre- and post-gadolinium enhanced fat-suppressed T1WI for the contrast-enhancement ratio (CER). A region of interest was drawn for each lesion for parameter measurements. The areas under the curve (AUC) of the parameters and their sensitivities and specificities at the most ideal cutoff values from receiver operating characteristic curve analysis were obtained. AUC, sensitivity, and specificity were respectively compared between FF and CER.



Results: The AUCs of FF, LDR, CER were 0.96, 0.80, and 0.72, respectively. In the comparison of diagnostic performance between FF and CER, FF showed a significantly larger AUC compared to CER (p = 0.030), although the difference of sensitivity (p = 0.157) and specificity (p = 0.157) were not significant.



Conclusion: Fat-signal fraction measurement using T2*-corrected three-echo VIBE DIXON sequence is feasible and shows more accurate diagnostic performance than CER in distinguishing benign red marrow deposition from malignant bone marrow-replacing lesions.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 2. Thesis
Yonsei Authors
Kim, Yong Pyo(김용표)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/148628
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