109 240

Cited 17 times in

Behavioral characteristics of a mouse model of cancer pain

Authors
 Bae Hwan Lee  ;  Jinsil Seong  ;  Un Jeng Kim  ;  Ran Won  ;  Jiyoung Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.46(2) : 252-259, 2005 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2005
MeSH
Animals ; Behavior, Animal* ; Bone and Bones/pathology ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cold Temperature ; Disease Models, Animal ; Foot ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C3H ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Neoplasms/complications* ; Pain/etiology* ; Pain/physiopathology ; Pain/psychology* ; Pain Threshold ; Physical Stimulation ; Thigh
Keywords
Cancer pain ; allodynia ; hyperalgesia ; behavior ; mouse
Abstract
Pain is a major symptom in cancer patients, and most cancer patients with advanced or terminal cancers suffer from chronic pain related to treatment failure and/or tumor progression. In the present study, we examined the development of cancer pain in mice. Murine hepatocarcinoma cells, HCa-1, were inoculated unilaterally into the thigh or the dorsum of the foot of male C3H/HeJ mice. Four weeks after inoculation, behavioral signs were observed for mechanical allodynia, cold allodynia, and hyperalgesia using a von Frey filament, acetone, and radiant heat, respectively. Bone invasion by the tumor commenced from 7 days after inoculation of tumor cells and was evident from 14 days after inoculation. Cold allodynia but neither mechanical allodynia nor hyperalgesia was observed in mice that received an inoculation into the thigh. On the contrary, mechanical allodynia and cold allodynia, but not hyperalgesia, were developed in mice with an inoculation into the foot. Sometimes, mirror-image pain was developed in these animals. These results suggest that carcinoma cells injected into the foot of mice may develop severe chronic pain related to cancer. This animal model of pain would be useful to elucidate the mechanisms of cancer pain in humans.
Files in This Item:
T200500348.pdf Download
DOI
10.3349/ymj.2005.46.2.252
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Un Jeng(김은정) ORCID logo https://orcid.org/0000-0003-0968-0252
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Won, Ran(원란)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147565
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links