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Cited 17 times in

Behavioral characteristics of a mouse model of cancer pain

DC FieldValueLanguage
dc.contributor.author성진실-
dc.contributor.author원란-
dc.contributor.author이배환-
dc.contributor.author김은정-
dc.date.accessioned2017-05-04T07:38:00Z-
dc.date.available2017-05-04T07:38:00Z-
dc.date.issued2005-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147565-
dc.description.abstractPain is a major symptom in cancer patients, and most cancer patients with advanced or terminal cancers suffer from chronic pain related to treatment failure and/or tumor progression. In the present study, we examined the development of cancer pain in mice. Murine hepatocarcinoma cells, HCa-1, were inoculated unilaterally into the thigh or the dorsum of the foot of male C3H/HeJ mice. Four weeks after inoculation, behavioral signs were observed for mechanical allodynia, cold allodynia, and hyperalgesia using a von Frey filament, acetone, and radiant heat, respectively. Bone invasion by the tumor commenced from 7 days after inoculation of tumor cells and was evident from 14 days after inoculation. Cold allodynia but neither mechanical allodynia nor hyperalgesia was observed in mice that received an inoculation into the thigh. On the contrary, mechanical allodynia and cold allodynia, but not hyperalgesia, were developed in mice with an inoculation into the foot. Sometimes, mirror-image pain was developed in these animals. These results suggest that carcinoma cells injected into the foot of mice may develop severe chronic pain related to cancer. This animal model of pain would be useful to elucidate the mechanisms of cancer pain in humans.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBehavior, Animal*-
dc.subject.MESHBone and Bones/pathology-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCold Temperature-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFoot-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C3H-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Transplantation-
dc.subject.MESHNeoplasms/complications*-
dc.subject.MESHPain/etiology*-
dc.subject.MESHPain/physiopathology-
dc.subject.MESHPain/psychology*-
dc.subject.MESHPain Threshold-
dc.subject.MESHPhysical Stimulation-
dc.subject.MESHThigh-
dc.titleBehavioral characteristics of a mouse model of cancer pain-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Physiology (생리학교실)-
dc.contributor.googleauthorBae Hwan Lee-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorUn Jeng Kim-
dc.contributor.googleauthorRan Won-
dc.contributor.googleauthorJiyoung Kim-
dc.identifier.doi10.3349/ymj.2005.46.2.252-
dc.contributor.localIdA01956-
dc.contributor.localIdA02430-
dc.contributor.localIdA02791-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid15861499-
dc.subject.keywordCancer pain-
dc.subject.keywordallodynia-
dc.subject.keywordhyperalgesia-
dc.subject.keywordbehavior-
dc.subject.keywordmouse-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameWon, Ran-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.citation.volume46-
dc.citation.number2-
dc.citation.startPage252-
dc.citation.endPage259-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.46(2) : 252-259, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid40338-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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