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Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque

Authors
 Young Won Yoon  ;  Hyuck Moon Kwon  ;  Ki-Chul Hwang  ;  Eui-Young Choi  ;  Bum-kee Hong  ;  Dongsoo Kim  ;  Hyun-Seung Kim  ;  Sang Ho Cho  ;  Kyung Soon Song  ;  Giuseppe Sangiorgi 
Citation
 ATHEROSCLEROSIS, Vol.180(1) : 37-44, 2005 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2005
MeSH
Adolescent ; Adult ; Aged ; Antigens, CD/metabolism* ; Basigin ; Blotting, Western ; Carotid Artery Diseases/metabolism* ; Carotid Artery Diseases/pathology ; Extracellular Matrix Proteins/metabolism* ; Gelatin ; Humans ; Immunohistochemistry ; Interleukin-1/pharmacology ; Matrix Metalloproteinase 2/metabolism* ; Matrix Metalloproteinase 9/metabolism* ; Middle Aged ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tissue Inhibitor of Metalloproteinase-2/metabolism
Keywords
Matrix metalloproteinases ; EMMPRIN ; Destabilizing atheroma
Abstract
From experimental and clinical studies it is known that matrix conservation and degradation by matrix metalloproteinases (MMPs) plays a major role in plaque progression and destabilization with related onset of acute vascular events such as acute coronary syndromes or cerebrovascular accidents. Recently, extracellular MMPs inducer (EMMPRIN) has been reported to induce and activate the expression of MMPs in myocardium and plays an important role in the ventricular remodeling in human heart failure. Similarly to heart failure myocardium, EMMPRIN may be expressed in human atheroma and play a role in the extracellular matrix (ECM) remodeling and atherogenic cell differentiation. This study was designed to investigate the possible biological role of EMMPRIN in human atheroma. Immunohistochemical analysis for MMPs and EMMPRIN was performed on human carotid endarterectomy specimens and control aortas. EMMPRIN showed significant immunoreactivity in human atherosclerotic carotid lesions, and was colocalized with macrophage/monocyte infiltrates in atherosclerotic intima, plaque itself and vascular smooth muscle cells (VSMCs). Zymography and Western blot analysis revealed EMMPRIN expression in the carotid atheromas, but not in the control aortas. Human bone marrow monocytes, which were cultured with atherogenic proinflammatory cytokine stimulation revealed increased EMMPRIN and MMPs expressions. ECM remodeling is under the control of induction and inhibition of matrix degrading protease and the novel MMP inducer, EMMPRIN may play a role in influx and differentiation of monocytes and destabilizing atheroma.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915004006306
DOI
10.1016/j.atherosclerosis.2004.11.021
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Dong Soo(김동수)
Kim, Hyun Seung(김현승)
Song, Kyung Soon(송경순)
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Cho, Sang Ho(조상호)
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147548
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