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Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque

DC FieldValueLanguage
dc.contributor.author권혁문-
dc.contributor.author김동수-
dc.contributor.author김현승-
dc.contributor.author송경순-
dc.contributor.author윤영원-
dc.contributor.author조상호-
dc.contributor.author최의영-
dc.contributor.author홍범기-
dc.contributor.author황기철-
dc.date.accessioned2017-05-04T07:37:09Z-
dc.date.available2017-05-04T07:37:09Z-
dc.date.issued2005-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147548-
dc.description.abstractFrom experimental and clinical studies it is known that matrix conservation and degradation by matrix metalloproteinases (MMPs) plays a major role in plaque progression and destabilization with related onset of acute vascular events such as acute coronary syndromes or cerebrovascular accidents. Recently, extracellular MMPs inducer (EMMPRIN) has been reported to induce and activate the expression of MMPs in myocardium and plays an important role in the ventricular remodeling in human heart failure. Similarly to heart failure myocardium, EMMPRIN may be expressed in human atheroma and play a role in the extracellular matrix (ECM) remodeling and atherogenic cell differentiation. This study was designed to investigate the possible biological role of EMMPRIN in human atheroma. Immunohistochemical analysis for MMPs and EMMPRIN was performed on human carotid endarterectomy specimens and control aortas. EMMPRIN showed significant immunoreactivity in human atherosclerotic carotid lesions, and was colocalized with macrophage/monocyte infiltrates in atherosclerotic intima, plaque itself and vascular smooth muscle cells (VSMCs). Zymography and Western blot analysis revealed EMMPRIN expression in the carotid atheromas, but not in the control aortas. Human bone marrow monocytes, which were cultured with atherogenic proinflammatory cytokine stimulation revealed increased EMMPRIN and MMPs expressions. ECM remodeling is under the control of induction and inhibition of matrix degrading protease and the novel MMP inducer, EMMPRIN may play a role in influx and differentiation of monocytes and destabilizing atheroma.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, CD/metabolism*-
dc.subject.MESHBasigin-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCarotid Artery Diseases/metabolism*-
dc.subject.MESHCarotid Artery Diseases/pathology-
dc.subject.MESHExtracellular Matrix Proteins/metabolism*-
dc.subject.MESHGelatin-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInterleukin-1/pharmacology-
dc.subject.MESHMatrix Metalloproteinase 2/metabolism*-
dc.subject.MESHMatrix Metalloproteinase 9/metabolism*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHTissue Inhibitor of Metalloproteinase-1/metabolism-
dc.subject.MESHTissue Inhibitor of Metalloproteinase-2/metabolism-
dc.titleUpstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque-
dc.typeArticle-
dc.publisher.locationIreland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorYoung Won Yoon-
dc.contributor.googleauthorHyuck Moon Kwon-
dc.contributor.googleauthorKi-Chul Hwang-
dc.contributor.googleauthorEui-Young Choi-
dc.contributor.googleauthorBum-kee Hong-
dc.contributor.googleauthorDongsoo Kim-
dc.contributor.googleauthorHyun-Seung Kim-
dc.contributor.googleauthorSang Ho Cho-
dc.contributor.googleauthorKyung Soon Song-
dc.contributor.googleauthorGiuseppe Sangiorgi-
dc.identifier.doi10.1016/j.atherosclerosis.2004.11.021-
dc.contributor.localIdA00260-
dc.contributor.localIdA00405-
dc.contributor.localIdA01120-
dc.contributor.localIdA02011-
dc.contributor.localIdA02580-
dc.contributor.localIdA03825-
dc.contributor.localIdA04165-
dc.contributor.localIdA04394-
dc.contributor.localIdA04456-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid15823273-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0021915004006306-
dc.subject.keywordMatrix metalloproteinases-
dc.subject.keywordEMMPRIN-
dc.subject.keywordDestabilizing atheroma-
dc.contributor.alternativeNameKwon, Hyuck Moon-
dc.contributor.alternativeNameKim, Dong Soo-
dc.contributor.alternativeNameKim, Hyun Seung-
dc.contributor.alternativeNameSong, Kyung Soon-
dc.contributor.alternativeNameYoon, Young Won-
dc.contributor.alternativeNameCho, Sang Ho-
dc.contributor.alternativeNameChoi, Eui Young-
dc.contributor.alternativeNameHong, Bum Kee-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.citation.volume180-
dc.citation.number1-
dc.citation.startPage37-
dc.citation.endPage44-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.180(1) : 37-44, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers

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