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Sulindac sulfide-induced apoptosis in sinonasal cancer cells

 Chang-Hoon Kim  ;  Kyoung Seob Song  ;  Kyung-Su Kim  ;  Jin Young Kim  ;  Bong-Jae Lee  ;  Jeung-Gweon Lee  ;  Joo-Heon Yoon 
 ACTA OTO-LARYNGOLOGICA, Vol.125(2) : 201-206, 2005 
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Issue Date
Amino Acid Chloromethyl Ketones/administration & dosage ; Amino Acid Chloromethyl Ketones/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology* ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use* ; Apoptosis/drug effects* ; Carcinoma, Squamous Cell/drug therapy* ; Carcinoma, Squamous Cell/pathology ; Caspase Inhibitors ; Flavonoids/administration & dosage ; Flavonoids/pharmacology ; Fluorescence ; Humans ; Imidazoles/administration & dosage ; Imidazoles/pharmacology ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; Paranasal Sinus Neoplasms/drug therapy* ; Paranasal Sinus Neoplasms/pathology ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Signal Transduction/drug effects ; Sulindac/analogs & derivatives* ; Sulindac/pharmacology* ; Sulindac/therapeutic use*
CONCLUSIONS: These results demonstrate that sulindac sulfide can induce cell death in maxillary cancer cells, and that sulindac sulfide-induced apoptosis is related to the extracellular signal-regulated kinase/p38 MAPK-caspase 3 signaling pathway. OBJECTIVE: Head and neck cancer is the sixth commonest cancer in the human body. Squamous cell carcinoma accounts for most sinonasal cancers. However, little is known regarding the biochemical mechanism(s) of cell death in sinonasal cancers. Recently, human epidemiological and clinical intervention studies have indicated that sulindac, a non-steroidal anti-inflammatory drug, exhibits chemopreventive activity in colorectal cancer. In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells. MATERIAL AND METHODS: Sinonasal cancer cells (Asan Medical Center Head and Neck Cancer 5) were treated with various concentrations of sulindac sulfide. The degree of cell death was determined by means of a fluorescence-activated cell scan and the signal transduction pathway for cell death was examined. RESULTS: Human nasal cavity cancer cells treated with sulindac sulfide underwent cell death, and the induction of apoptosis occurred in a dose-dependent manner. Moreover, sulindac sulfide-induced apoptosis was abolished by treatment with the caspase inhibitor Z-VAD-fmk and the mitogen-activated protein kinase (MAPK) inhibitors PD98059 and SB203580.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
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