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Sulindac sulfide-induced apoptosis in sinonasal cancer cells

DC FieldValueLanguage
dc.contributor.author김경수-
dc.contributor.author김창훈-
dc.contributor.author윤주헌-
dc.contributor.author이정권-
dc.date.accessioned2017-05-04T07:36:18Z-
dc.date.available2017-05-04T07:36:18Z-
dc.date.issued2005-
dc.identifier.issn0001-6489-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147531-
dc.description.abstractCONCLUSIONS: These results demonstrate that sulindac sulfide can induce cell death in maxillary cancer cells, and that sulindac sulfide-induced apoptosis is related to the extracellular signal-regulated kinase/p38 MAPK-caspase 3 signaling pathway. OBJECTIVE: Head and neck cancer is the sixth commonest cancer in the human body. Squamous cell carcinoma accounts for most sinonasal cancers. However, little is known regarding the biochemical mechanism(s) of cell death in sinonasal cancers. Recently, human epidemiological and clinical intervention studies have indicated that sulindac, a non-steroidal anti-inflammatory drug, exhibits chemopreventive activity in colorectal cancer. In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells. MATERIAL AND METHODS: Sinonasal cancer cells (Asan Medical Center Head and Neck Cancer 5) were treated with various concentrations of sulindac sulfide. The degree of cell death was determined by means of a fluorescence-activated cell scan and the signal transduction pathway for cell death was examined. RESULTS: Human nasal cavity cancer cells treated with sulindac sulfide underwent cell death, and the induction of apoptosis occurred in a dose-dependent manner. Moreover, sulindac sulfide-induced apoptosis was abolished by treatment with the caspase inhibitor Z-VAD-fmk and the mitogen-activated protein kinase (MAPK) inhibitors PD98059 and SB203580.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherTaylor & Francis-
dc.relation.isPartOfACTA OTO-LARYNGOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAmino Acid Chloromethyl Ketones/administration & dosage-
dc.subject.MESHAmino Acid Chloromethyl Ketones/pharmacology-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/pharmacology*-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/therapeutic use*-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHCarcinoma, Squamous Cell/drug therapy*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCaspase Inhibitors-
dc.subject.MESHFlavonoids/administration & dosage-
dc.subject.MESHFlavonoids/pharmacology-
dc.subject.MESHFluorescence-
dc.subject.MESHHumans-
dc.subject.MESHImidazoles/administration & dosage-
dc.subject.MESHImidazoles/pharmacology-
dc.subject.MESHMitogen-Activated Protein Kinases/antagonists & inhibitors-
dc.subject.MESHMitogen-Activated Protein Kinases/metabolism-
dc.subject.MESHParanasal Sinus Neoplasms/drug therapy*-
dc.subject.MESHParanasal Sinus Neoplasms/pathology-
dc.subject.MESHPyridines/administration & dosage-
dc.subject.MESHPyridines/pharmacology-
dc.subject.MESHSignal Transduction/drug effects-
dc.subject.MESHSulindac/analogs & derivatives*-
dc.subject.MESHSulindac/pharmacology*-
dc.subject.MESHSulindac/therapeutic use*-
dc.titleSulindac sulfide-induced apoptosis in sinonasal cancer cells-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorChang-Hoon Kim-
dc.contributor.googleauthorKyoung Seob Song-
dc.contributor.googleauthorKyung-Su Kim-
dc.contributor.googleauthorJin Young Kim-
dc.contributor.googleauthorBong-Jae Lee-
dc.contributor.googleauthorJeung-Gweon Lee-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.identifier.doiOAK-2005-03095-
dc.contributor.localIdA00298-
dc.contributor.localIdA01050-
dc.contributor.localIdA02604-
dc.contributor.localIdA03095-
dc.relation.journalcodeJ00028-
dc.identifier.eissn1651-2251-
dc.identifier.pmid15880954-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.1080/00016480410020293-
dc.subject.keyword15880954-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.alternativeNameKim, Chang Hoon-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameLee, Jeung Gweon-
dc.citation.volume125-
dc.citation.number2-
dc.citation.startPage201-
dc.citation.endPage206-
dc.identifier.bibliographicCitationACTA OTO-LARYNGOLOGICA, Vol.125(2) : 201-206, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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