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Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy vs Laser In Situ Keratomileusis

 Hyung Keun Lee  ;  Kyung Sub Lee  ;  Hyeon Chang Kim  ;  Sung Ho Lee  ;  Eung Kweon Kim 
 AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.139(6) : 965-971, 2005 
Journal Title
Issue Date
Adult ; Astigmatism/surgery ; Cornea/physiology ; Cornea/surgery ; Corneal Diseases/etiology ; Corneal Diseases/metabolism* ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/metabolism* ; Enzyme-Linked Immunosorbent Assay ; Eye Proteins/metabolism* ; Female ; Humans ; Keratomileusis, Laser In Situ/adverse effects* ; Lasers, Excimer ; Male ; Myopia/surgery ; Nerve Growth Factor/metabolism* ; Photorefractive Keratectomy/adverse effects* ; Prospective Studies ; Sensation/physiology ; Tears/metabolism*
PURPOSE: To determine whether tear nerve growth factor (NGF) concentration correlates with corneal sensation and ocular surface dryness after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). DESIGN: Prospective, nonrandomized comparative clinical trial. METHODS: Seventy eyes of 35 patients and 76 eyes of 38 patients underwent PRK and LASIK procedures to correct myopia and myopic astigmatism, respectively. Total tear protein level, tear NGF concentration, tear film breakup time (BUT) and Schirmer values were measured before and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery. RESULTS: The postoperative mean tear NGF/total tear protein (NGF/tP) ratio increased in both PRK and LASIK patients compared with preoperative levels (P < .0001). At 1 week and 1 month postoperatively, the NGF/tP ratio was higher in PRK than in LASIK subjects (P < .0001). Before 6 months postoperatively, the mean corneal sensation after LASIK in the ablated zone was lower than the preoperative sensation (P < .0001), but this was not the case in PRK subjects. Mean BUT and Schirmer values were significantly lower in LASIK-treated eyes compared with PRK-treated eyes up to 6 months postoperatively (P < .0001). The early postoperative tear NGF/tP ratio correlated with the postoperative 6-month value of corneal sensation, BUT, and Schirmer values. CONCLUSIONS: The difference in the postoperative corneal sensation and ocular surface dryness between PRK-treated and LASIK-treated eyes might be related to the difference in the early postoperative levels of NGF, which is a potent nerve growth stimulator.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
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