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Plasma surface modification of poly (d,l-lactic-co-glycolic acid) (65/35) film for tissue engineering

Authors
 Gyu Ha Ryu  ;  Won-Sun Yang  ;  Hye-Won Roh  ;  In-Seop Lee  ;  Jeong Koo Kim  ;  Gun Hwan Lee  ;  Dong Hee Lee  ;  Bong Joo Park  ;  Min Sub Lee  ;  Jong-Chul Park 
Citation
 SURFACE & COATINGS TECHNOLOGY, Vol.193(1~3) : 60-64, 2005 
Journal Title
 SURFACE & COATINGS TECHNOLOGY 
ISSN
 0257-8972 
Issue Date
2005
MeSH
Plasma treatment ; PLGA film ; Tissue engineering ; Human dermal fibroblast ; Rat cortical neural cell
Keywords
Plasma treatment ; PLGA film ; Tissue engineering ; Human dermal fibroblast ; Rat cortical neural cell
Abstract
Plasma technique can easily be used to introduce desired functional groups or chains onto the surface of materials, so it has a special application to improve the cell affinity of scaffolds. Additionally, it has been demonstrated that plasma treatment is a unique and powerful method for modifying polymeric materials without altering their bulk properties. Cell affinity is the most important factor to be considered when biodegradable polymeric materials such as poly (d,l-lactic-co-glycolic acid) (PLGA) are utilized as a cell scaffold in tissue engineering. In this study, PLGA surface was modified with TiO2 using magnetron sputtering in order to improve PLGA surface/cells interaction. The changes of surface properties have been characterized by contact angle measurement and X-ray photoelectron spectroscopy (XPS). To confirm the attachment or proliferation of human dermal fibroblasts and rat cortical neural cells, MTT assay and scanning electron microscopy (SEM) were carried out. The results indicated that TiO2-coated PLGA film became hydrophilic and enhanced cell affinity and/or proliferation. It has been suggested that TiO2-coated PLGA matrix can be a candidate for cell scaffolds in tissue engineering.
Full Text
http://www.sciencedirect.com/science/article/pii/S025789720400533X
DOI
10.1016/j.surfcoat.2004.07.062
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Bong Joo(박봉주)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Dong Hee(이동희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147301
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