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Elevated serum aminotransferase level as a predictor of intracerebral hemorrhage: Korea Medical Insurance Corporation study

 Hyeon Chang Kim  ;  Dae Ryong Kang  ;  Chung Mo Nam  ;  Nam Wook Hur  ;  Jee Seon Shim  ;  Sun Ha Jee  ;  Il Suh 
 STROKE, Vol.36(8) : 1642-1647, 2005 
Journal Title
Issue Date
Adult ; Alanine Transaminase/blood ; Aspartic Acid/blood ; Blood Pressure ; Brain Ischemia/blood ; Cerebral Hemorrhage/blood* ; Cerebral Hemorrhage/diagnosis* ; Female ; Follow-Up Studies ; Glucose/metabolism ; Humans ; Korea ; Male ; Middle Aged ; Obesity ; Proportional Hazards Models ; Risk ; Risk Factors ; Stroke/pathology ; Subarachnoid Hemorrhage/blood ; Time Factors ; Transaminases/blood*
BACKGROUND AND PURPOSE: Serum aminotransferase levels are known to be associated with cardiovascular risk factors, but the relation with stroke incidence is not well known. We investigated the relation between serum aminotransferase levels and the incidence of stroke. METHODS: We measured serum aspartate and alanine aminotransferase levels and traditional cardiovascular risk factors in 108 464 Korean men, aged 35 to 59 years, in 1990 and 1992. Serum aminotransferase levels were classified into 3 categories (<35, 35 to 69, and > or =70 IU/L). The outcomes were hospital admissions and deaths from stroke subtypes (ischemic stroke, intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) from 1993 to 2002. RESULTS: During the 10 years, 1728 ischemic, 1051 hemorrhagic (718 ICH and 222 SAH), and 243 unspecified stroke events occurred. After adjustment for age and other traditional risk factors and according to Cox proportional-hazards models, serum aminotransferase level had an independent positive associations with ICH. However, ischemic stroke and SAH were not associated with aminotransferase levels. Compared with the level <35 IU/L, the adjusted relative risks (95% confidence interval) of ICH for an aspartate aminotransferase level of 35 to 69 and > or =70 IU/L were 1.49 (1.21 to 1.83) and 4.21 (3.06 to 5.77), respectively. The corresponding risks for alanine aminotransferase were 1.34 (1.09 to 1.65) and 2.89 (2.09 to 4.01), respectively. These associations were consistent regardless of the level of obesity, blood pressure, fasting glucose, alcohol intake, and follow-up length. CONCLUSIONS: These findings suggest that an elevated aminotransferase level is a predictor of ICH. The biologic significance of aminotransferase level for the development of ICH merits further study.
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Appears in Collections:
5. Research Institutes (연구소) > Institute for Environmental Research (환경공해연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kang, Dae Ryong(강대용)
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Shim, Jee Seon(심지선) ORCID logo https://orcid.org/0000-0002-8671-3153
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Hur, Nam Wook(허남욱)
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