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Frontostriatal Connectivity Changes in Major Depressive Disorder After Repetitive Transcranial Magnetic Stimulation: A Randomized Sham-Controlled Study.

 Jee In Kang  ;  Hyeongrae Lee  ;  Kyungun Jhung  ;  Kyung Ran Kim  ;  Suk Kyoon An  ;  Kang-Jun Yoon  ;  Sun I. Kim  ;  Kee Namkoong  ;  Eun Lee 
 JOURNAL OF CLINICAL PSYCHIATRY, Vol.77(9) : 1137-1143, 2016 
Journal Title
Issue Date
Adult ; Aged ; Caudate Nucleus/physiopathology* ; Connectome/methods* ; Depressive Disorder, Major/physiopathology* ; Depressive Disorder, Major/therapy* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Outcome Assessment (Health Care)* ; Prefrontal Cortex/physiopathology* ; Transcranial Magnetic Stimulation/methods* ; Young Adult
OBJECTIVE: The aim of this randomized, sham-controlled study was to investigate the therapeutic effects of underlying neurobiological changes after 2-week repetitive transcranial magnetic stimulation (rTMS) treatment using functional connectivity magnetic resonance imaging in patients with major depression.
METHODS: Twenty-four patients with major depressive disorder diagnosed with DSM-IV-TR criteria were randomly assigned to the active rTMS (n = 13) or sham (n = 11) groups from January 2009 to June 2011. rTMS was given for 2 weeks at 110% of the motor threshold for 10 minutes at 10 Hz over the left dorsolateral prefrontal cortex (DLPFC). Resting state functional connectivity was evaluated before and after rTMS. The 17-item Hamilton Depression Rating Scale (HDRS) was administered, and neurocognitive tasks were performed. We examined between-group differences in functional connectivity changes from the bilateral DLPFC.
RESULTS: Participants in the active rTMS group showed significant clinical improvement in HDRS scores compared to those in the sham group (P < .001). After 2-week rTMS, there were significant differences in changes in DLPFC-left caudate connectivity (corrected P < .05): the active group showed a greater reduction of connectivity strength between the DLPFC and left caudate compared to the sham group. Reduced levels of DLPFC-left caudate connectivity predicted improvement in depressive symptoms (r = 0.58, P = .001). Additionally, a positive correlation between residual depressive symptoms and connectivity strength after 2-week rTMS was found (r = 0.46, P = .023).
CONCLUSIONS: High-frequency rTMS over the left DLPFC showed therapeutic effects in patients with major depression. The therapeutic effect of rTMS is related to the modulation of functional connectivity in the frontostriatal network.
TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01325831.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
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