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Metabolite-selective hyperpolarized (13)C imaging using extended chemical shift displacement at 9.4T.

Authors
 Seungwook Yang  ;  Joonsung Lee  ;  Eunhae Joe  ;  Hansol Lee  ;  Young-Suk Choi  ;  Jae Mo Park  ;  Daniel Spielman  ;  Ho-Taek Song  ;  Dong-Hyun Kim 
Citation
 MAGNETIC RESONANCE IMAGING, Vol.34(4) : 535-540, 2016 
Journal Title
 MAGNETIC RESONANCE IMAGING 
ISSN
 0730-725X 
Issue Date
2016
MeSH
Animals ; Artifacts ; Carbon Isotopes/analysis ; Kidney/diagnostic imaging* ; Magnetic Resonance Spectroscopy/methods* ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phantoms, Imaging
Keywords
(13)C ; 9.4T ; Chemical shift displacement ; Hyperpolarized ; Metabolic imaging
Abstract
PURPOSE: To develop a technique for frequency-selective hyperpolarized (13)C metabolic imaging in ultra-high field strength which exploits the broad spatial chemical shift displacement in providing spectral and spatial selectivity. METHODS: The spatial chemical shift displacement caused by the slice-selection gradient was utilized in acquiring metabolite-selective images. Interleaved images of different metabolites were acquired by reversing the polarity of the slice-selection gradient at every repetition time, while using a low-bandwidth radio-frequency excitation pulse to alternatingly shift the displaced excitation bands outside the imaging subject. Demonstration of this technique is presented using (1)H phantom and in vivo mouse renal hyperpolarized (13)C imaging experiments with conventional chemical shift imaging and fast low-angle shot sequences. RESULTS: From phantom and in vivo mouse studies, the spectral selectivity of the proposed method is readily demonstrated using results of chemical shift spectroscopic imaging, which displayed clearly delineated images of different metabolites. Imaging results using the proposed method without spectral encoding also showed effective separation while also providing high spatial resolution. CONCLUSION: This method provides a way to acquire spectrally selective hyperpolarized (13)C metabolic images in a simple implementation, and with potential ability to support combination with more elaborate readout methods for faster imaging.
Full Text
http://www.sciencedirect.com/science/article/pii/S0730725X15003185
DOI
10.1016/j.mri.2015.12.023
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
Yonsei Authors
Choi, Young Suk(최영숙) ORCID logo https://orcid.org/0000-0003-4930-8455
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147139
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