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Effect of major histocompatibility complex haplotype matching by C4 and MICA genotyping on acute graft versus host disease in unrelated hematopoietic stem cell transplantation.

 Yongjung Park  ;  June-Won Cheong  ;  Myoung Hee Park  ;  Myoung Soo Kim  ;  Jong Sun Kim  ;  Hyon-Suk Kim 
 HUMAN IMMUNOLOGY, Vol.77(2) : 176-183, 2016 
Journal Title
Issue Date
Acute Disease ; Adult ; Complement C4/genetics* ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Graft vs Host Disease/genetics* ; Graft vs Host Disease/immunology ; Hematopoietic Stem Cell Transplantation* ; Histocompatibility/genetics ; Histocompatibility Antigens Class I/genetics* ; Histocompatibility Testing ; Humans ; Linkage Disequilibrium ; Male ; Polymorphism, Genetic ; Young Adult
C4 gene ; Graft versus host disease ; Hematopoietic stem cell transplantation ; Human leukocyte antigen ; MHC class I polypeptide-related sequence A
We explored whether matching of human leukocyte antigen (HLA) haplotypes between the recipient and donor of hematopoietic stem cell transplantation (HSCT) predicted by C4 and MICA typing is associated with the incidence of acute graft versus host disease (aGVHD). DNA preparations collected from a total of 81 recipient and donor pairs were used for PCR-based C4 subtyping and/or MICA sequence-based typing. Incidences of aGVHD were compared according to C4 and MICA matching. The six most common MICA alleles were MICA*008:01, *010:01, *002:01, *004, *009:01/049, and *012:01. Among the 59 unrelated pairs, HLA alleles were matched in 34 (57.6%). C4 subtypes were identical between the recipient and donor in 28 (82.4%) HLA-matched unrelated pairs, while MICA genotypes were matched in all HLA-matched unrelated pairs. In the 22 HLA-matched related pairs, all recipients showed identical C4 subtypes with their respective donors. In multivariate analysis, C4 mismatch was a significant risk factor associated with the development of aGVHD in unrelated HSCT (hazard ratio=3.24, P=0.006). PCR-based C4 subtyping is a simple method for assessing the genetic identity of the HLA region between a recipient and unrelated donor. This test would be also useful for prediction of aGVHD in HSCT.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
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