0 358

Cited 6 times in

Inhibitory Effect of Chrysin (5,7-Dihydroxyflavone) on Experimental Choroidal Neovascularization in Rats.

Authors
 Song J.H.  ;  Kim Y.H.  ;  Lee S.C.  ;  Kim M.H.  ;  Lee J.H. 
Citation
 OPHTHALMIC RESEARCH, Vol.56(1) : 49-55, 2016 
Journal Title
OPHTHALMIC RESEARCH
ISSN
 0030-3747 
Issue Date
2016
MeSH
Animals ; Choroidal Neovascularization/drug therapy* ; Choroidal Neovascularization/pathology ; Disease Models, Animal ; Flavonoids/administration & dosage* ; Fluorescein Angiography ; Fundus Oculi ; Intravitreal Injections ; Male ; Rats ; Rats, Inbred BN ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Keywords
ChrysinFluorescein ; angiographyIntravitreal ; injectionLaser-induced ; choroidal ; neovascularization
Abstract
PURPOSE: The aim of this study was to evaluate the effect of chrysin on laser-induced experimental choroidal neovascularization (CNV) in a rat model.
METHODS: Male brown Norway rats were anesthetized, and a diode laser was used to break Bruch's membrane. One week later, each rat was intravitreally injected with 5 µl of 15 mg/ml chrysin, and CNV development was determined by fluorescein angiography at 2 weeks. The effect of chrysin on experimental CNV was assessed by fluorescein angiography and histology.
RESULTS: Two weeks after laser treatment, the intensity of fluorescein leakage from the photocoagulated lesions decreased significantly compared with the control group (p = 0.044). When the lesions were categorized into low- and high-leakage groups, there was a significant correlation between chrysin treatment and degree of leakage (p = 0.028). Compared with the chrysin-treated group, the relative risk of developing high-leakage lesions in the control group was 3.18. The mean CNV thickness was significantly thinner in chrysin-treated eyes than in control eyes (34.13 ±.0.88 vs. 37.76 ± 0.90 μm, p = 0.005).
CONCLUSION: Chrysin has an inhibitory effect on CNV in an experimental rat model, indicating that chrysin should be further evaluated for its potential as a therapy for CNV in age-related macular degeneration and in other vision-threatening conditions associated with CNV.
Full Text
http://www.karger.com/Article/Abstract/444929
DOI
10.1159/000444929
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Ji Hwan(이지환) ORCID logo https://orcid.org/0000-0003-1759-8195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147109
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links