Cited 12 times in
Inhibitory Effect of Chrysin (5,7-Dihydroxyflavone) on Experimental Choroidal Neovascularization in Rats.
DC Field | Value | Language |
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dc.contributor.author | 이성철 | - |
dc.contributor.author | 이지환 | - |
dc.date.accessioned | 2017-02-27T08:12:01Z | - |
dc.date.available | 2017-02-27T08:12:01Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0030-3747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147109 | - |
dc.description.abstract | PURPOSE: The aim of this study was to evaluate the effect of chrysin on laser-induced experimental choroidal neovascularization (CNV) in a rat model. METHODS: Male brown Norway rats were anesthetized, and a diode laser was used to break Bruch's membrane. One week later, each rat was intravitreally injected with 5 µl of 15 mg/ml chrysin, and CNV development was determined by fluorescein angiography at 2 weeks. The effect of chrysin on experimental CNV was assessed by fluorescein angiography and histology. RESULTS: Two weeks after laser treatment, the intensity of fluorescein leakage from the photocoagulated lesions decreased significantly compared with the control group (p = 0.044). When the lesions were categorized into low- and high-leakage groups, there was a significant correlation between chrysin treatment and degree of leakage (p = 0.028). Compared with the chrysin-treated group, the relative risk of developing high-leakage lesions in the control group was 3.18. The mean CNV thickness was significantly thinner in chrysin-treated eyes than in control eyes (34.13 ±.0.88 vs. 37.76 ± 0.90 μm, p = 0.005). CONCLUSION: Chrysin has an inhibitory effect on CNV in an experimental rat model, indicating that chrysin should be further evaluated for its potential as a therapy for CNV in age-related macular degeneration and in other vision-threatening conditions associated with CNV. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 49~55 | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | OPHTHALMIC RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Choroidal Neovascularization/drug therapy* | - |
dc.subject.MESH | Choroidal Neovascularization/pathology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Flavonoids/administration & dosage* | - |
dc.subject.MESH | Fluorescein Angiography | - |
dc.subject.MESH | Fundus Oculi | - |
dc.subject.MESH | Intravitreal Injections | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Inbred BN | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/antagonists & inhibitors | - |
dc.title | Inhibitory Effect of Chrysin (5,7-Dihydroxyflavone) on Experimental Choroidal Neovascularization in Rats. | - |
dc.type | Article | - |
dc.publisher.location | Switzerland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Song J.H. | - |
dc.contributor.googleauthor | Kim Y.H. | - |
dc.contributor.googleauthor | Lee S.C. | - |
dc.contributor.googleauthor | Kim M.H. | - |
dc.contributor.googleauthor | Lee J.H. | - |
dc.identifier.doi | 10.1159/000444929 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A03222 | - |
dc.relation.journalcode | J02428 | - |
dc.identifier.eissn | 1423-0259 | - |
dc.identifier.pmid | 27058958 | - |
dc.identifier.url | http://www.karger.com/Article/Abstract/444929 | - |
dc.subject.keyword | ChrysinFluorescein | - |
dc.subject.keyword | angiographyIntravitreal | - |
dc.subject.keyword | injectionLaser-induced | - |
dc.subject.keyword | choroidal | - |
dc.subject.keyword | neovascularization | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.alternativeName | Lee, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Sung Chul | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hwan | - |
dc.citation.volume | 56 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 55 | - |
dc.identifier.bibliographicCitation | OPHTHALMIC RESEARCH, Vol.56(1) : 49-55, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47141 | - |
dc.type.rims | ART | - |
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