Cited 23 times in
Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동준 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 이지환 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2017-02-27T08:10:50Z | - |
dc.date.available | 2017-02-27T08:10:50Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147104 | - |
dc.description.abstract | PURPOSE: We aimed to evaluate the therapeutic effect and complications of combined intravitreal melphalan and intravenous/intra-arterial chemotherapy as a primary approach for retinoblastoma with vitreous seeds. METHODS: In this retrospective case series, eight eyes from eight retinoblastoma patients with vitreous seeds were included. All eyes received 20-30 μg of intravitreal melphalan accompanied by intravenous and intra-arterial chemotherapy. Triple freeze-thaw cryotherapy was performed when withdrawing the needle from the eye to prevent tumor dissemination. RESULTS: Tumors and vitreous seeds regressed in all eyes. The mean number of intravitreal melphalan injections was 3.25 (median 3.50, range 2-4). Globe salvage was attained in seven of eight eyes (87.5 %). Enucleation was performed in one case, in which the pathologic section showed no residual tumor and tumor-free resection margins. Serous retinal detachment was observed in four eyes (50 %), and vitreous hemorrhage developed in two (25 %). Retinal pigment epithelium atrophy or mottling was found in three eyes (37.5 %). There were no cases of extraocular tumor extension or remote metastasis. CONCLUSIONS: Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy was effective for tumor and vitreous seeding control, but vision-threatening complications such as vitreous hemorrhage or serous retinal detachment occurred in half the cases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 391~394 | - |
dc.language | English, German | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents, Alkylating/administration & dosage* | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/administration & dosage | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infusions, Intra-Arterial | - |
dc.subject.MESH | Infusions, Intravenous | - |
dc.subject.MESH | Intravitreal Injections | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Melphalan/administration & dosage* | - |
dc.subject.MESH | Neoplasm Seeding* | - |
dc.subject.MESH | Retinal Neoplasms/drug therapy* | - |
dc.subject.MESH | Retinal Neoplasms/pathology | - |
dc.subject.MESH | Retinoblastoma/drug therapy* | - |
dc.subject.MESH | Retinoblastoma/secondary | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Vitreous Body/pathology* | - |
dc.title | Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Ji Hwan Lee | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Seung Min Hahn | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Dong Joon Kim | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.identifier.doi | 10.1007/s00417-015-3202-0 | - |
dc.contributor.localId | A00410 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A03222 | - |
dc.contributor.localId | A04299 | - |
dc.contributor.localId | A04325 | - |
dc.relation.journalcode | J00951 | - |
dc.identifier.eissn | 1435-702X | - |
dc.identifier.pmid | 26511530 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s00417-015-3202-0 | - |
dc.subject.keyword | Combined modality therapy | - |
dc.subject.keyword | Intravitreal injections | - |
dc.subject.keyword | Melphalan | - |
dc.subject.keyword | Neoplasm seeding | - |
dc.subject.keyword | Retinoblastoma | - |
dc.contributor.alternativeName | Kim, Dong Joon | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.alternativeName | Lee, Ji Hwan | - |
dc.contributor.alternativeName | Hahn, Seung Min | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Joon | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Lee, Sung Chul | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Hahn, Seung Min | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.citation.volume | 254 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 391 | - |
dc.citation.endPage | 394 | - |
dc.identifier.bibliographicCitation | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.254(2) : 391-394, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47136 | - |
dc.type.rims | ART | - |
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