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Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds

DC FieldValueLanguage
dc.contributor.author김동준-
dc.contributor.author유철주-
dc.contributor.author이성철-
dc.contributor.author이지환-
dc.contributor.author한승민-
dc.contributor.author한정우-
dc.date.accessioned2017-02-27T08:10:50Z-
dc.date.available2017-02-27T08:10:50Z-
dc.date.issued2016-
dc.identifier.issn0721-832X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147104-
dc.description.abstractPURPOSE: We aimed to evaluate the therapeutic effect and complications of combined intravitreal melphalan and intravenous/intra-arterial chemotherapy as a primary approach for retinoblastoma with vitreous seeds. METHODS: In this retrospective case series, eight eyes from eight retinoblastoma patients with vitreous seeds were included. All eyes received 20-30 μg of intravitreal melphalan accompanied by intravenous and intra-arterial chemotherapy. Triple freeze-thaw cryotherapy was performed when withdrawing the needle from the eye to prevent tumor dissemination. RESULTS: Tumors and vitreous seeds regressed in all eyes. The mean number of intravitreal melphalan injections was 3.25 (median 3.50, range 2-4). Globe salvage was attained in seven of eight eyes (87.5 %). Enucleation was performed in one case, in which the pathologic section showed no residual tumor and tumor-free resection margins. Serous retinal detachment was observed in four eyes (50 %), and vitreous hemorrhage developed in two (25 %). Retinal pigment epithelium atrophy or mottling was found in three eyes (37.5 %). There were no cases of extraocular tumor extension or remote metastasis. CONCLUSIONS: Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy was effective for tumor and vitreous seeding control, but vision-threatening complications such as vitreous hemorrhage or serous retinal detachment occurred in half the cases.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent391~394-
dc.languageEnglish, German-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents, Alkylating/administration & dosage*-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/administration & dosage-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfusions, Intra-Arterial-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHIntravitreal Injections-
dc.subject.MESHMale-
dc.subject.MESHMelphalan/administration & dosage*-
dc.subject.MESHNeoplasm Seeding*-
dc.subject.MESHRetinal Neoplasms/drug therapy*-
dc.subject.MESHRetinal Neoplasms/pathology-
dc.subject.MESHRetinoblastoma/drug therapy*-
dc.subject.MESHRetinoblastoma/secondary-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHVitreous Body/pathology*-
dc.titleCombined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorJi Hwan Lee-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorSeung Min Hahn-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorDong Joon Kim-
dc.contributor.googleauthorSung Chul Lee-
dc.identifier.doi10.1007/s00417-015-3202-0-
dc.contributor.localIdA00410-
dc.contributor.localIdA02524-
dc.contributor.localIdA02873-
dc.contributor.localIdA03222-
dc.contributor.localIdA04299-
dc.contributor.localIdA04325-
dc.relation.journalcodeJ00951-
dc.identifier.eissn1435-702X-
dc.identifier.pmid26511530-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s00417-015-3202-0-
dc.subject.keywordCombined modality therapy-
dc.subject.keywordIntravitreal injections-
dc.subject.keywordMelphalan-
dc.subject.keywordNeoplasm seeding-
dc.subject.keywordRetinoblastoma-
dc.contributor.alternativeNameKim, Dong Joon-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.alternativeNameLee, Ji Hwan-
dc.contributor.alternativeNameHahn, Seung Min-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorKim, Dong Joon-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.contributor.affiliatedAuthorLee, Ji Hwan-
dc.contributor.affiliatedAuthorHahn, Seung Min-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.citation.volume254-
dc.citation.number2-
dc.citation.startPage391-
dc.citation.endPage394-
dc.identifier.bibliographicCitationGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.254(2) : 391-394, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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