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Toxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic airway inflammation in mice.

 Heejae Han  ;  Yoon Hee Park  ;  Hye Jung Park  ;  Kangtaek Lee  ;  Kiju Um  ;  Jung-Won Park  ;  Jae-Hyun Lee 
 RESPIRATORY RESEARCH, Vol.17(1) : 60, 2016 
Journal Title
Issue Date
Animals ; Bronchial Hyperreactivity/chemically induced ; Bronchial Hyperreactivity/physiopathology ; Bronchoalveolar Lavage Fluid/chemistry ; Bronchoconstriction/drug effects ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Inflammation Mediators/metabolism ; Inhalation Exposure ; Lung/drug effects* ; Lung/immunology ; Lung/metabolism ; Lung/physiopathology ; Mice, Inbred BALB C ; Nanoparticles/chemistry ; Nanoparticles/toxicity* ; Ovalbumin* ; Pneumonia/chemically induced* ; Pneumonia/immunology ; Pneumonia/metabolism ; Pneumonia/physiopathology ; Polyethylene Glycols/toxicity ; Porosity ; Silicon Dioxide/chemistry ; Silicon Dioxide/toxicity*
Adjuvant effect ; Airway Inflammation ; Nanoparticle ; PEGylation ; Silica ; Toxicity
BACKGROUND: Silica nanoparticles (SNPs) can easily enter in respiratory system via inhalation because of their low molecular weight and ease of dispersion. Toxicity and adverse effects of SNPs vary according to the physical characteristics of the particle. METHODS: To evaluate the toxic and adjuvant effects of 3 types of SNPs in the airway system, six-week-old female BALB/c mice were intranasally administered 3 types of SNPs (spherical [S-SNP], mesoporous [M-SNP], and polyethylene glycol-conjugated [P-SNP]) alone or SNPs/ovalbumin (OVA), three times weekly for 2 weeks. Airway hyper-responsiveness (AHR), bronchoalveolar lavage fluid (BALF), cytokine levels, and histology of the lungs were analyzed. RESULTS: The S-SNPs/OVA group and M-SNPs/OVA group showed significant AHR, compared to the control group. Among all SNP-treated groups, the group administered SNPs/OVA showed greater inflammatory cell infiltration in BALF, extensive pathological changes, and higher cytokine levels (IL-5, IL-13, IL-1β, and IFN-γ) than those administered SNPs alone or saline/OVA. CONCLUSION: Exposure to SNPs alone and SNPs/OVA induced toxicity in the respiratory system. SNPs alone showed significant toxic effects on the airway system. Meanwhile, SNPs/OVA exerted adjuvant effects to OVA of inducing allergic airway inflammation. In particular, M-SNPs showed the most severe airway inflammation in both direct toxicity and adjuvant effect assays. P-SNPs induced less inflammation than the other types of SNPs in both models.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Park, Hye Jung(박혜정) ORCID logo https://orcid.org/0000-0002-1862-1003
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
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