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Toxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic airway inflammation in mice.

DC FieldValueLanguage
dc.contributor.author박중원-
dc.contributor.author박혜정-
dc.contributor.author이재현-
dc.date.accessioned2017-02-27T07:58:37Z-
dc.date.available2017-02-27T07:58:37Z-
dc.date.issued2016-
dc.identifier.issn1465-9921-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147047-
dc.description.abstractBACKGROUND: Silica nanoparticles (SNPs) can easily enter in respiratory system via inhalation because of their low molecular weight and ease of dispersion. Toxicity and adverse effects of SNPs vary according to the physical characteristics of the particle. METHODS: To evaluate the toxic and adjuvant effects of 3 types of SNPs in the airway system, six-week-old female BALB/c mice were intranasally administered 3 types of SNPs (spherical [S-SNP], mesoporous [M-SNP], and polyethylene glycol-conjugated [P-SNP]) alone or SNPs/ovalbumin (OVA), three times weekly for 2 weeks. Airway hyper-responsiveness (AHR), bronchoalveolar lavage fluid (BALF), cytokine levels, and histology of the lungs were analyzed. RESULTS: The S-SNPs/OVA group and M-SNPs/OVA group showed significant AHR, compared to the control group. Among all SNP-treated groups, the group administered SNPs/OVA showed greater inflammatory cell infiltration in BALF, extensive pathological changes, and higher cytokine levels (IL-5, IL-13, IL-1β, and IFN-γ) than those administered SNPs alone or saline/OVA. CONCLUSION: Exposure to SNPs alone and SNPs/OVA induced toxicity in the respiratory system. SNPs alone showed significant toxic effects on the airway system. Meanwhile, SNPs/OVA exerted adjuvant effects to OVA of inducing allergic airway inflammation. In particular, M-SNPs showed the most severe airway inflammation in both direct toxicity and adjuvant effect assays. P-SNPs induced less inflammation than the other types of SNPs in both models.-
dc.description.statementOfResponsibilityopen-
dc.format.extent60-
dc.languageEnglish-
dc.publisherBioMed Central Ltd-
dc.relation.isPartOfRESPIRATORY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBronchial Hyperreactivity/chemically induced-
dc.subject.MESHBronchial Hyperreactivity/physiopathology-
dc.subject.MESHBronchoalveolar Lavage Fluid/chemistry-
dc.subject.MESHBronchoconstriction/drug effects-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHInflammation Mediators/metabolism-
dc.subject.MESHInhalation Exposure-
dc.subject.MESHLung/drug effects*-
dc.subject.MESHLung/immunology-
dc.subject.MESHLung/metabolism-
dc.subject.MESHLung/physiopathology-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHNanoparticles/chemistry-
dc.subject.MESHNanoparticles/toxicity*-
dc.subject.MESHOvalbumin*-
dc.subject.MESHPneumonia/chemically induced*-
dc.subject.MESHPneumonia/immunology-
dc.subject.MESHPneumonia/metabolism-
dc.subject.MESHPneumonia/physiopathology-
dc.subject.MESHPolyethylene Glycols/toxicity-
dc.subject.MESHPorosity-
dc.subject.MESHSilicon Dioxide/chemistry-
dc.subject.MESHSilicon Dioxide/toxicity*-
dc.titleToxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic airway inflammation in mice.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHeejae Han-
dc.contributor.googleauthorYoon Hee Park-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorKangtaek Lee-
dc.contributor.googleauthorKiju Um-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.identifier.doi10.1186/s12931-016-0376-x-
dc.contributor.localIdA01681-
dc.contributor.localIdA01769-
dc.contributor.localIdA03086-
dc.relation.journalcodeJ02616-
dc.identifier.eissn1465-993X-
dc.identifier.pmid27194244-
dc.subject.keywordAdjuvant effect-
dc.subject.keywordAirway Inflammation-
dc.subject.keywordNanoparticle-
dc.subject.keywordPEGylation-
dc.subject.keywordSilica-
dc.subject.keywordToxicity-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorPark, Hye Jung-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage60-
dc.identifier.bibliographicCitationRESPIRATORY RESEARCH, Vol.17(1) : 60, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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