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Is Pre-Operative Axillary Staging with Ultrasound and Ultrasound-Guided Fine-Needle Aspiration Reliable in Invasive Lobular Carcinoma of the Breast?

Authors
 SOO-YEON KIM  ;  EUN-KYUNG KIM  ;  HEE JUNG MOON  ;  JUNG HYUN YOON  ;  MIN JUNG KIM 
Citation
 ULTRASOUND IN MEDICINE AND BIOLOGY, Vol.42(6) : 1263-1272, 2016 
Journal Title
 ULTRASOUND IN MEDICINE AND BIOLOGY 
ISSN
 0301-5629 
Issue Date
2016
MeSH
Adult ; Aged ; Axilla/diagnostic imaging ; Axilla/pathology ; Breast/pathology ; Breast Neoplasms/pathology* ; Carcinoma, Lobular/pathology* ; Female ; Humans ; Lymph Nodes/diagnostic imaging* ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Preoperative Care/methods* ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Ultrasonography/methods* ; Ultrasonography, Interventional/methods
Keywords
Axillary lymph node metastasis ; Breast ; Fine-needle aspiration ; Lobular carcinoma ; Ultrasound
Abstract
Axillary ultrasound (US) with US-guided fine-needle aspiration (US-FNA) for suspicious lymph nodes is important for pre-operative staging and planning of surgical management. Invasive lobular carcinoma (ILC) metastases were previously thought to be difficult to detect, but with a limited amount of evidence. This study investigated the ability of US and US-FNA to detect ILC metastases by assessing 142 patients with ILC. The sensitivity of US in detection of metastasis was 52.3%, and US was able to exclude 96% of N2 and N3 axillary metastases. The false-negative rate of US-FNA in detection of metastasis for suspicious lymph nodes on US was 34.8%, and lymph nodes with longer maximal dimensions were associated with false-negative US-FNA results. Multiplicity of breast lesions and maximal cortical thickness ≥3.1 mm of lymph nodes were independently associated with metastasis. Although pre-operative US in ILC can reliably exclude advanced axillary nodal disease, US-FNA results should be carefully interpreted.
Full Text
http://www.sciencedirect.com/science/article/pii/S0301562916000417
DOI
10.1016/j.ultrasmedbio.2016.01.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146947
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