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Abdominal Aortic Calcification in Living Kidney Donors.

Authors
 Y.E. Yoon  ;  W.K. Han  ;  H.H. Lee  ;  M.-Y. Chang  ;  K.H. Huh  ;  D.C. Jung  ;  Y.S. Kim  ;  Y.T. Oh 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.48(3) : 720-724, 2016 
Journal Title
TRANSPLANTATION PROCEEDINGS
ISSN
 0041-1345 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Aorta, Abdominal/diagnostic imaging* ; Aorta, Abdominal/pathology ; Arteriosclerosis/etiology ; Arteriosclerosis/pathology ; Biomarkers/analysis ; Biopsy ; Female ; Humans ; Kidney/physiopathology ; Living Donors* ; Male ; Middle Aged ; Nephrectomy/adverse effects* ; Nephrosclerosis/diagnostic imaging ; Nephrosclerosis/etiology ; Recovery of Function ; Tissue and Organ Harvesting/adverse effects* ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/etiology*
Abstract
OBJECTIVE: This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis.
METHODS: Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis.
RESULTS: The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P < .001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P = .035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P = .022), tubular atrophy (62.5% vs 33.1%; P = .002), and a higher nephrosclerosis score (P = .002).
CONCLUSIONS: Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134516002773
DOI
10.1016/j.transproceed.2016.02.037
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Yoon, Young Eun(윤영은)
Lee, Hyung Ho(이형호)
Jung, Dae Chul(정대철) ORCID logo https://orcid.org/0000-0001-5769-5083
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146934
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