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Abdominal Aortic Calcification in Living Kidney Donors.

 Y.E. Yoon  ;  W.K. Han  ;  H.H. Lee  ;  M.-Y. Chang  ;  K.H. Huh  ;  D.C. Jung  ;  Y.S. Kim  ;  Y.T. Oh 
 Transplantation Proceedings, Vol.48(3) : 720-724, 2016 
Journal Title
 Transplantation Proceedings 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Aorta, Abdominal/diagnostic imaging* ; Aorta, Abdominal/pathology ; Arteriosclerosis/etiology ; Arteriosclerosis/pathology ; Biomarkers/analysis ; Biopsy ; Female ; Humans ; Kidney/physiopathology ; Living Donors* ; Male ; Middle Aged ; Nephrectomy/adverse effects* ; Nephrosclerosis/diagnostic imaging ; Nephrosclerosis/etiology ; Recovery of Function ; Tissue and Organ Harvesting/adverse effects* ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/etiology*
OBJECTIVE: This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. METHODS: Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. RESULTS: The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P < .001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P = .035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P = .022), tubular atrophy (62.5% vs 33.1%; P = .002), and a higher nephrosclerosis score (P = .002). CONCLUSIONS: Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
오영택(Oh, Young Taik) ORCID logo https://orcid.org/0000-0002-4438-8890
윤영은(Yoon, Young Eun)
이형호(Lee, Hyung Ho)
정대철(Jung, Dae Chul) ORCID logo https://orcid.org/0000-0001-5769-5083
한웅규(Han, Woong Kyu) ORCID logo https://orcid.org/0000-0002-2527-4046
허규하(Huh, Kyu Ha) ORCID logo https://orcid.org/0000-0003-1364-6989
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