Cited 26 times in

Asymptomatic Benign Papilloma Without Atypia Diagnosed at Ultrasonography-Guided 14-Gauge Core Needle Biopsy: Which Subgroup can be Managed by Observation?

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author김민정-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author윤정현-
dc.contributor.author이혜선-
dc.date.accessioned2017-02-27T07:30:02Z-
dc.date.available2017-02-27T07:30:02Z-
dc.date.issued2016-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146896-
dc.description.abstractBACKGROUND: For asymptomatic benign papillomas detected at ultrasonography-guided 14-gauge core-needle biopsy (US-CNB), the decision to perform excision versus observation has been a topic of debate. We sought to determine which subgroup of asymptomatic benign papillomas without atypia diagnosed at US-CNB can be safely managed by observation versus immediate excision. MATERIALS: Overall, 230 asymptomatic benign papillomas in 197 women (mean age 46.6 ± 9.5 years; range 22-78), diagnosed at US-CNB using immunohistochemistry staining when needed and then managed by surgery (n = 144) or vacuum-assisted excision (VAE) with at least 12 months of follow-up after benign VAE results (n = 86) were included in this study. The upgrade rate to malignancy was calculated. Clinical and radiological variables, including age, size, Breast Image Reporting and Data System (BI-RADS) category, and imaging-pathology correlation were evaluated to find associations with malignancy using multivariate analysis. RESULTS: The upgrade rate to malignancy was 2.6 % (6 of 230): four were ductal carcinomas in situ and two were 1.5- and 9-mm-sized invasive ductal carcinomas without lymph node metastasis. The upgrade rates of papillomas with a BI-RADS category 3-4a and imaging-pathology concordance were 1.4 and 1.8 %, respectively. Category 4b-5 and imaging-pathology discordance were independently associated with malignancy, with upgrade rates of 13 and 50 %, respectively. Age and lesion size were not associated with malignancy. CONCLUSION: Asymptomatic benign papillomas with probable benign or low suspicious US features or imaging-pathology concordance can be followed-up as opposed to immediate excision.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent1860~1866-
dc.publisherSpringer-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiopsy, Large-Core Needle-
dc.subject.MESHBreast Neoplasms/diagnosis*-
dc.subject.MESHBreast Neoplasms/diagnostic imaging-
dc.subject.MESHBreast Neoplasms/surgery-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/diagnosis*-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/diagnostic imaging-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/surgery-
dc.subject.MESHDisease Management-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHImage-Guided Biopsy/methods*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHObservational Studies as Topic-
dc.subject.MESHPapilloma/diagnosis*-
dc.subject.MESHPapilloma/diagnostic imaging-
dc.subject.MESHPapilloma/surgery-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHUltrasonography, Mammary/methods*-
dc.subject.MESHYoung Adult-
dc.titleAsymptomatic Benign Papilloma Without Atypia Diagnosed at Ultrasonography-Guided 14-Gauge Core Needle Biopsy: Which Subgroup can be Managed by Observation?-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorSoo-Yeon Kim-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorHee Jung Moon-
dc.identifier.doi10.1245/s10434-016-5144-0-
dc.contributor.localIdA00198-
dc.contributor.localIdA00473-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02595-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid26920388-
dc.identifier.urlhttp://link.springer.com/article/10.1245/s10434-016-5144-0-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Min Jung-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume23-
dc.citation.number6-
dc.citation.startPage1860-
dc.citation.endPage1866-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.23(6) : 1860-1866, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid46462-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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