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Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A₂ in Mice.

Authors
 Dasom Shin  ;  Gihyun Lee  ;  Sung-Hwa Sohn  ;  Soojin Park  ;  Kyung-Hwa Jung  ;  Ji Min Lee  ;  Jieun Yang  ;  Jaeho Cho  ;  Hyunsu Bae 
Citation
 TOXINS, Vol.8(5) : 131, 2016 
Journal Title
 TOXINS 
Issue Date
2016
MeSH
Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use* ; Bee Venoms/enzymology* ; Female ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Lung/radiation effects ; Mice, Inbred C57BL ; Phospholipases A2/pharmacology ; Phospholipases A2/therapeutic use* ; Radiation Pneumonitis/drug therapy* ; Radiation Pneumonitis/immunology ; Radiation Pneumonitis/pathology ; T-Lymphocytes, Regulatory/immunology*
Keywords
bee venom ; inflammation ; phospholipase A2 ; radiotherapy ; regulatory T cells
Abstract
Bee venom has long been used to treat various inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. Previously, we reported that bee venom phospholipase A₂ (bvPLA₂) has an anti-inflammatory effect through the induction of regulatory T cells. Radiotherapy is a common anti-cancer method, but often causes adverse effects, such as inflammation. This study was conducted to evaluate the protective effects of bvPLA₂ in radiation-induced acute lung inflammation. Mice were focally irradiated with 75 Gy of X-rays in the lung and administered bvPLA₂ six times after radiation. To evaluate the level of inflammation, the number of immune cells, mRNA level of inflammatory cytokine, and histological changes in the lung were measured. BvPLA₂ treatment reduced the accumulation of immune cells, such as macrophages, neutrophils, lymphocytes, and eosinophils. In addition, bvPLA₂ treatment decreased inflammasome-, chemokine-, cytokine- and fibrosis-related genes' mRNA expression. The histological results also demonstrated the attenuating effect of bvPLA₂ on radiation-induced lung inflammation. Furthermore, regulatory T cell depletion abolished the therapeutic effects of bvPLA₂ in radiation-induced pneumonitis, implicating the anti-inflammatory effects of bvPLA₂ are dependent upon regulatory T cells. These results support the therapeutic potential of bvPLA₂ in radiation pneumonitis and fibrosis treatments.
Files in This Item:
T201601386.pdf Download
DOI
10.3390/toxins8050131
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Sung Hwa(손성화)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146824
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