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Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A₂ in Mice.

DC Field Value Language
dc.contributor.author손성화-
dc.contributor.author조재호-
dc.date.accessioned2017-02-24T11:39:38Z-
dc.date.available2017-02-24T11:39:38Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146824-
dc.description.abstractBee venom has long been used to treat various inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. Previously, we reported that bee venom phospholipase A₂ (bvPLA₂) has an anti-inflammatory effect through the induction of regulatory T cells. Radiotherapy is a common anti-cancer method, but often causes adverse effects, such as inflammation. This study was conducted to evaluate the protective effects of bvPLA₂ in radiation-induced acute lung inflammation. Mice were focally irradiated with 75 Gy of X-rays in the lung and administered bvPLA₂ six times after radiation. To evaluate the level of inflammation, the number of immune cells, mRNA level of inflammatory cytokine, and histological changes in the lung were measured. BvPLA₂ treatment reduced the accumulation of immune cells, such as macrophages, neutrophils, lymphocytes, and eosinophils. In addition, bvPLA₂ treatment decreased inflammasome-, chemokine-, cytokine- and fibrosis-related genes' mRNA expression. The histological results also demonstrated the attenuating effect of bvPLA₂ on radiation-induced lung inflammation. Furthermore, regulatory T cell depletion abolished the therapeutic effects of bvPLA₂ in radiation-induced pneumonitis, implicating the anti-inflammatory effects of bvPLA₂ are dependent upon regulatory T cells. These results support the therapeutic potential of bvPLA₂ in radiation pneumonitis and fibrosis treatments.-
dc.description.statementOfResponsibilityopen-
dc.format.extentE131-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfTOXINS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnti-Inflammatory Agents/pharmacology-
dc.subject.MESHAnti-Inflammatory Agents/therapeutic use*-
dc.subject.MESHBee Venoms/enzymology*-
dc.subject.MESHFemale-
dc.subject.MESHLung/drug effects-
dc.subject.MESHLung/immunology-
dc.subject.MESHLung/pathology-
dc.subject.MESHLung/radiation effects-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHPhospholipases A2/pharmacology-
dc.subject.MESHPhospholipases A2/therapeutic use*-
dc.subject.MESHRadiation Pneumonitis/drug therapy*-
dc.subject.MESHRadiation Pneumonitis/immunology-
dc.subject.MESHRadiation Pneumonitis/pathology-
dc.subject.MESHT-Lymphocytes, Regulatory/immunology*-
dc.titleRegulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A₂ in Mice.-
dc.typeArticle-
dc.publisher.locationSwitzerland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorDasom Shin-
dc.contributor.googleauthorGihyun Lee-
dc.contributor.googleauthorSung-Hwa Sohn-
dc.contributor.googleauthorSoojin Park-
dc.contributor.googleauthorKyung-Hwa Jung-
dc.contributor.googleauthorJi Min Lee-
dc.contributor.googleauthorJieun Yang-
dc.contributor.googleauthorJaeho Cho-
dc.contributor.googleauthorHyunsu Bae-
dc.identifier.doi10.3390/toxins8050131-
dc.contributor.localIdA04587-
dc.contributor.localIdA03901-
dc.relation.journalcodeJ02746-
dc.identifier.eissn2072-6651-
dc.identifier.pmid27144583-
dc.subject.keywordbee venom-
dc.subject.keywordinflammation-
dc.subject.keywordphospholipase A2-
dc.subject.keywordradiotherapy-
dc.subject.keywordregulatory T cells-
dc.contributor.alternativeNameSohn, Sung Hwa-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.affiliatedAuthorSohn, Sung Hwa-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.citation.volume8-
dc.citation.number5-
dc.citation.startPage131-
dc.identifier.bibliographicCitationTOXINS, Vol.8(5) : 131, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47566-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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