319 479

Cited 4 times in

Glycated Albumin is Independently Associated With Arterial Stiffness in Non-Diabetic Chronic Kidney Disease Patients

 Hoon Young Choi  ;  Seung Kyo Park  ;  Gi Young Yun  ;  Ah Ran Choi  ;  Jung Eun Lee  ;  Sung Kyu Ha  ;  Hyeong Cheon Park 
 MEDICINE, Vol.95(16) : 3362, 2016 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Ankle Brachial Index ; Blood Pressure/physiology* ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Diabetic Nephropathies/blood* ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/physiopathology ; Female ; Follow-Up Studies ; Glomerular Filtration Rate/physiology ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Plethysmography ; Prognosis ; Pulsatile Flow/physiology ; Renal Insufficiency, Chronic/blood* ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/physiopathology ; Retrospective Studies ; Risk Factors ; Serum Albumin/metabolism* ; Vascular Stiffness/physiology*
Glycated albumin (GA) exhibits atherogenic effects and increased serum GA levels are associated with the development of cardiovascular complications in diabetic patients. GA production also increases with aging, oxidative stress, and renal dysfunction. We performed this study to further ascertain the association between GA and arterial stiffness in nondiabetic chronic kidney disease (CKD) patients. We enrolled 129 nondiabetic CKD patients. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV) using a volume plethysmographic instrument along with simultaneous measurements of GA. Insulin resistance was determined with the homeostatic model assessment. The estimated glomerular filtration rate was calculated using serum creatinine and cystatin C according to the CKD-EPI Creatinine-Cystatin C equation adjusted for age, sex, and race (eGFRcr-cys). Nondiabetic CKD patients with arterial stiffness (baPWV ≥1400 cm/s) showed higher GA levels than those without arterial stiffness (14.2 [8.7-20.2]% vs 13.0 [8.8-18.9]%, P = 0.004). In the subgroup analysis, the patients who had both a higher GA level and a lower eGFRcr-cys, showed the highest baPWV compared with patients with a higher GA or a lower GFR alone. By Spearman's correlation analysis, GA correlated significantly with baPWV (r = +0.291, P = 0.001) and fasting serum glucose level (r = +0.191, P = 0.030), whereas The homeostatic model assessment of insulin resistance did not show any significant correlation with baPWV. Systolic blood pressure (r = +0.401 P < 0.001), age (r = +0.574, P < 0.001), high-density lipoprotein (HDL)-cholesterol level (r = -0.317, P < 0.001), and eGFRcr-cys (r = -0.285, P = 0.002) had a significant correlation with baPWV. According to multivariable logistic regression analysis, higher GA and systolic blood pressure were the independent risk factors affecting arterial stiffness. Our results suggest that serum GA is a potential risk factor of arterial stiffness in nondiabetic CKD patients.
Files in This Item:
T201601273.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Ha, Sung Kyu(하성규)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.