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Histone H3K27 Demethylase JMJD3 in Cooperation with NF-κB Regulates Keratinocyte Wound Healing

Authors
 Jungtae Na  ;  Kwanghyun Lee  ;  Wonho Na  ;  Jee-Yoon Shin  ;  Min-Jung Lee  ;  Tae Young Yune  ;  Hae Kwang Lee  ;  Han-Sung Jung  ;  Won Sun Kim  ;  Bong-Gun Ju 
Citation
 JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.136(4) : 847-858, 2016 
Journal Title
JOURNAL OF INVESTIGATIVE DERMATOLOGY
ISSN
 0022-202X 
Issue Date
2016
MeSH
Animals ; Cell Differentiation ; Cell Line ; Cell Proliferation ; Gene Expression Regulation* ; Gene Expression Regulation, Enzymologic ; Histones/chemistry ; Humans ; Inflammation ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism* ; Keratinocytes/cytology ; Keratinocytes/enzymology* ; Male ; Mice ; Mice, Inbred ICR ; NF-kappa B p50 Subunit/metabolism* ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction ; Skin/metabolism ; Wound Healing*
Abstract
Histone H3K27me3 demethylase JMJD3 has been shown to be involved in keratinocyte differentiation and wound healing. However, the exact molecular mechanism underlying JMJD3-mediated keratinocyte wound healing has not been fully elucidated. In this study, we report on the biological function of JMJD3 in keratinocyte wound healing using in vitro cell and in vivo animal models. Our results indicate that JMJD3 up-regulation and NF-κB activation occur in the region of the wound edge during keratinocyte wound healing. We also found that JMJD3 interacts with NF-κB, resulting in increased expression of the inflammatory, matrix metalloproteinase, and growth factor genes via demethylation of H3K27me3 at the gene promoters. Consistently, inactivation of JMJD3 or NF-κB resulted in aberrant keratinocyte wound healing. Our study suggests that regulation of JMJD3 may provide a new therapeutic intervention for treating the chronic skin wound.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022202X16003432
DOI
10.1016/j.jid.2015.11.029
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146690
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