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Histone H3K27 Demethylase JMJD3 in Cooperation with NF-κB Regulates Keratinocyte Wound Healing

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dc.contributor.author정한성-
dc.date.accessioned2017-02-24T11:12:24Z-
dc.date.available2017-02-24T11:12:24Z-
dc.date.issued2016-
dc.identifier.issn0022-202X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146690-
dc.description.abstractHistone H3K27me3 demethylase JMJD3 has been shown to be involved in keratinocyte differentiation and wound healing. However, the exact molecular mechanism underlying JMJD3-mediated keratinocyte wound healing has not been fully elucidated. In this study, we report on the biological function of JMJD3 in keratinocyte wound healing using in vitro cell and in vivo animal models. Our results indicate that JMJD3 up-regulation and NF-κB activation occur in the region of the wound edge during keratinocyte wound healing. We also found that JMJD3 interacts with NF-κB, resulting in increased expression of the inflammatory, matrix metalloproteinase, and growth factor genes via demethylation of H3K27me3 at the gene promoters. Consistently, inactivation of JMJD3 or NF-κB resulted in aberrant keratinocyte wound healing. Our study suggests that regulation of JMJD3 may provide a new therapeutic intervention for treating the chronic skin wound.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent847~858-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF INVESTIGATIVE DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCell Line-
dc.subject.MESHCell Proliferation-
dc.subject.MESHGene Expression Regulation*-
dc.subject.MESHGene Expression Regulation, Enzymologic-
dc.subject.MESHHistones/chemistry-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHJumonji Domain-Containing Histone Demethylases/genetics-
dc.subject.MESHJumonji Domain-Containing Histone Demethylases/metabolism*-
dc.subject.MESHKeratinocytes/cytology-
dc.subject.MESHKeratinocytes/enzymology*-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHNF-kappa B p50 Subunit/metabolism*-
dc.subject.MESHRNA Interference-
dc.subject.MESHRNA, Small Interfering/metabolism-
dc.subject.MESHSignal Transduction-
dc.subject.MESHSkin/metabolism-
dc.subject.MESHWound Healing*-
dc.titleHistone H3K27 Demethylase JMJD3 in Cooperation with NF-κB Regulates Keratinocyte Wound Healing-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorJungtae Na-
dc.contributor.googleauthorKwanghyun Lee-
dc.contributor.googleauthorWonho Na-
dc.contributor.googleauthorJee-Yoon Shin-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorTae Young Yune-
dc.contributor.googleauthorHae Kwang Lee-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorWon Sun Kim-
dc.contributor.googleauthorBong-Gun Ju-
dc.identifier.doi10.1016/j.jid.2015.11.029-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ01469-
dc.identifier.eissn1523-1747-
dc.identifier.pmid26802933-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0022202X16003432-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.citation.volume136-
dc.citation.number4-
dc.citation.startPage847-
dc.citation.endPage858-
dc.identifier.bibliographicCitationJOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.136(4) : 847-858, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47435-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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