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Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea

Authors
 Byung Moon Kim  ;  Yong Sam Shin  ;  Min Woo Baik  ;  Deok Hee Lee  ;  Pyoung Jeon  ;  Seung Kug Baik  ;  Tae Hong Lee  ;  Dong-Hoon Kang  ;  Sang-il Suh  ;  Jun Soo Byun  ;  Jin-Young Jung  ;  Kihun Kwon  ;  Dong Joon Kim  ;  Keun Young Park  ;  Bum-soo Kim  ;  Jung Cheol Park  ;  Seong Rim Kim  ;  Young Woo Kim  ;  Hoon Kim  ;  Kyungil Jo  ;  Chang Hyo Yoon  ;  Young Soo Kim 
Citation
 Neurointervention, Vol.11(1) : 10-17, 2016 
Journal Title
 Neurointervention 
ISSN
 2093-9043 
Issue Date
2016
Keywords
Aneurysm ; Flow diverter ; Pipeline
Abstract
PURPOSE: The purpose of this study was to assess the safety and early outcomes of the Pipeline device for large/giant or fusiform aneurysms. MATERIALS AND METHODS: The Pipeline was implanted in a total of 45 patients (mean age, 58 years; M:F=10:35) with 47 large/giant or fusiform aneurysms. We retrospectively evaluated the characteristics of the treated aneurysms, the periprocedural events, morbidity and mortality, and the early outcomes after Pipeline implantation. RESULTS: The aneurysms were located in the internal carotid artery (ICA) cavernous segment (n=25), ICA intradural segment (n=11), vertebrobasilar trunk (n=8), and middle cerebral artery (n=3). Procedure-related events occurred in 18 cases, consisting of incomplete expansion (n=8), shortening-migration (n=5), transient occlusion of a jailed branch (n=3), and in-stent thrombosis (n=2). Treatment-related morbidity occurred in two patients, but without mortality. Both patients had modified Rankin scale (mRS) scores of 2, but had an improved mRS score of 0 at 1-month follow-up. Of the 19 patients presenting with mass effect, 16 improved but three showed no changes in their presenting symptoms. All patients had excellent outcomes (mRS, 0 or 1) during the follow-up period (median, 6 months; range, 2-30 months). Vascular imaging follow-up (n=31, 65.9%; median, 3 months, range, 1-25 months) showed complete or near occlusion of the aneurysm in 24 patients (77.4%) and decreased sac size in seven patients (22.6%). CONCLUSION: In this initial multicenter study in Korea, the Pipeline seemed to be safe and effective for large/giant or fusiform aneurysms. However, a learning period may be required to alleviate device-related events.
Files in This Item:
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DOI
10.5469/neuroint.2016.11.1.10
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Byung Moon(김병문) ORCID logo https://orcid.org/0000-0001-8593-6841
Park, Keun Young(박근영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146641
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