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Exploring Erythropoietin and G-CSF Combination Therapy in Chronic Stroke Patients

Authors
 Yoon-Kyum Shin  ;  Sung-Rae Cho 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.17(4) : 463, 2016 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2016
MeSH
Adult ; Antigens, CD34/metabolism ; Chronic Disease ; Double-Blind Method ; Drug Therapy, Combination ; Epoetin Alfa/therapeutic use* ; Female ; Granulocyte Colony-Stimulating Factor/therapeutic use* ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Leukocytes/cytology ; Leukocytes/metabolism ; Male ; Middle Aged ; Neuroprotective Agents/therapeutic use* ; Neutrophils/cytology ; Neutrophils/metabolism ; Pilot Projects ; Placebo Effect ; Stroke/drug therapy*
Keywords
combination therapy ; erythropoietin ; granulocyte-colony stimulating factor ; neuroprotection ; stroke
Abstract
Erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) are known to have neuroprotective actions. Based on previous reports showing the synergistic effects of EPO+G-CSF combination therapy in experimental models, we investigated the safety of EPO+G-CSF combination therapy in patients with chronic stroke. In a pilot study, 3 patients were treated with EPO and G-CSF for 5 consecutive days, with follow-up on day 30. In an exploratory double-blind study, 6 patients were allocated to treatment with either EPO+G-CSF or placebo. Treatment was applied once a day for 5 days per month over 3 months. Participants were followed up for 6 months. To substantiate safety, vital signs, adverse events, and hematological values were measured on days 0, 5, and 30 in each cycle and on day 180. Functional outcomes were determined on day 0 and 180. In the laboratory measurements, EPO+G-CSF combination therapy significantly elevated erythropoietin, CD34⁺ hematopoietic stem cells, white blood cells, and neutrophils on day 5 of each cycle. There were no observations of serious adverse events. In the functional outcomes, the grip power of the dominant hand was increased in the EPO+G-CSF treatment group. In conclusion, this exploratory study suggests a novel strategy of EPO+G-CSF combination therapy for stroke patients.
Files in This Item:
T201601233.pdf Download
DOI
10.3390/ijms17040463
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146635
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