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Safety and efficacy of tuberculin skin testing with microneedle MicronJet600™ in healthy adults

Authors
 H-J. Lee  ;  H-J. Choi  ;  D-R. Kim  ;  H. Lee  ;  J-E. Jin  ;  Y-R. Kim  ;  M-S. Lee  ;  S-N. Cho  ;  Y. A. Kang 
Citation
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.20(4) : 500-504, 2016 
Journal Title
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 
ISSN
 1027-3719 
Issue Date
2016
MeSH
Adult ; Asian Continental Ancestry Group ; Body Mass Index ; Dose-Response Relationship, Drug ; Female ; Humans ; Injections, Intradermal/adverse effects ; Injections, Intradermal/instrumentation ; Male ; Middle Aged ; Needles* ; Pain/diagnosis ; Pain/etiology ; Prospective Studies ; Republic of Korea ; Syringes ; Tuberculin/administration & dosage ; Tuberculin/immunology ; Tuberculin Test/adverse effects ; Tuberculin Test/instrumentation* ; Young Adult
Keywords
microneedle device ; TST ; Mantoux ; intradermal
Abstract
SETTING: Intradermal injection using a syringe and needle is generally accepted as the most accurate method for the tuberculin skin test (TST). However, the Mantoux technique using a conventional needle is often difficult to perform reliably, affecting testing results and safety. OBJECTIVE: We evaluated the efficacy and safety of a novel intradermal injection device, the MicronJet600(TM) microneedle, compared with conventional injection in terms of skin reactivity to the TST. DESIGN: A prospective, open-label clinical study was conducted. The TST was administered by both methods in the same subject. For pain assessment, participants filled in a visual analogue scale (VAS) after each TST. Any side effects due to TST or injections were observed. RESULTS: TST reaction rates (cut-off ⩾5 mm) from microneedles and needles were respectively 44.0% and 47.2%, with no significant difference between the two. Furthermore, agreement of positivity between the two methods was excellent with both 5 mm and 10 mm cut-off values. However, the level of pain experienced when microneedles were used for TST was significantly lower than with conventional needles. No adverse effects were attributed to the MicronJet device. CONCLUSION: The novel microneedle device used for TST in this study was effective, safe and less painful in healthy adult volunteers.
Files in This Item:
T201600889.pdf Download
DOI
10.5588/ijtld.15.0678
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Lee, Hyejon(이혜존) ORCID logo https://orcid.org/0000-0001-8207-537X
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146569
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