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Genetic analysis of ovarian microcystic stromal tumor

Authors
 Jae Hoon Lee  ;  Hyun-Soo Kim  ;  Nam Hoon Cho  ;  Jung-Yun Lee  ;  Sunghoon Kim  ;  Sang Wun Kim  ;  Young Tae Kim  ;  Eun Ji Nam 
Citation
 Obstetrics & Gynecology Science, Vol.59(2) : 157-162, 2016 
Journal Title
 Obstetrics & Gynecology Science 
ISSN
 2287-8572 
Issue Date
2016
Keywords
CTNNB1 mutation ; Microcystic stromal tumor ; Ovary ; Pyrosequencing
Abstract
Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cells of both cases were stained with CD10, vimentin, and Wilms tumor 1. Genetic analysis was performed and β-catenin gene (CTNNB1) mutation in exon 3 was detected in both cases. This is the first report in regards of detecting CTNNB1 mutation in ovarian MCST through the use of pyrosequencing (a novel sequencing technique).
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DOI
10.5468/ogs.2016.59.2.157
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김상운(Kim, Sang Wun) ORCID logo https://orcid.org/0000-0002-8342-8701
김성훈(Kim, Sung Hoon) ORCID logo https://orcid.org/0000-0002-1645-7473
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
김현수(Kim, Hyun-Soo)
남은지(Nam, Eun Ji)
이재훈(Lee, Jae Hoon)
이정윤(Lee, Jung-Yun) ORCID logo https://orcid.org/0000-0001-7948-1350
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146510
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