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Application of dynamic contrast-enhanced MRI parameters for differentiating squamous cell carcinoma and malignant lymphoma of the oropharynx

Authors
 Mina Park  ;  Jinna Kim  ;  Yoon Seong Choi  ;  Seung-Koo Lee  ;  Yoon Woo Koh  ;  Se-Heon Kim  ;  Eun Chang Choi 
Citation
 American Journal of Roentgenology, Vol.206(2) : 401-407, 2016 
Journal Title
 American Journal of Roentgenology 
ISSN
 0361-803X 
Issue Date
2016
MeSH
Adult ; Aged ; Carcinoma, Squamous Cell/diagnosis* ; Contrast Media ; Female ; Humans ; Imaging, Three-Dimensional ; Lymphoma/diagnosis* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Oropharyngeal Neoplasms/diagnosis*
Keywords
MRI ; head and neck cancer ; histogram analysis ; lymphoma ; squamous cell carcinoma
Abstract
OBJECTIVE: The purpose of this study was to investigate the usefulness of histogram analysis of dynamic contrast-enhanced MRI (DCE-MRI) parameters for the differentiation of squamous cell carcinoma (SCC) and malignant lymphoma of the oropharynx. MATERIALS AND METHODS: Pretreatment DCE-MRI was performed in 21 patients with pathologically confirmed oropharyngeal SCC and six patients with malignant lymphoma. DCE-MRI parameter maps including the volume transfer constant (K(trans)), flux rate constant (kep), and extravascular extracellular volume fraction (ve) based on the Tofts model were obtained. Enhancing tumors were manually segmented on each slice of the parameter maps, and the data were collected to obtain a histogram for the entire tumor volume. The Wilcoxon rank sum test was used to compare the histogram parameters of each DCE-MRI-derived variable of oropharyngeal SCC and lymphoma. RESULTS: Histogram analysis of K(trans) and ve maps revealed that the median and mode of K(trans) were significantly higher in SCC than in lymphoma (p = 0.039 and 0.032, respectively), and the mode, skewness, and kurtosis of ve were significantly different in SCC than in lymphoma (p = 0.046, 0.039, and 0.032, respectively). On ROC analysis, the kurtosis of ve had the best discriminative value for distinguishing between oropharyngeal SCC and lymphoma (AUC, 0.865; cutoff value, 2.60; sensitivity, 83.3%; specificity, 90.5%). CONCLUSION: Our preliminary evidence using histogram analysis of DCE-MRI parameters based on the whole tumor volume suggests that it might be useful for differentiating SCC from malignant lymphoma of the oropharynx.
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.15.14550
DOI
10.2214/AJR.15.14550
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
고윤우(Kho, Yoon Woo)
김세헌(Kim, Se Heon)
김진아(Kim, Jinna) ORCID logo https://orcid.org/0000-0002-9978-4356
박미나(Park, Mina) ORCID logo https://orcid.org/0000-0002-2005-7560
이승구(Lee, Seung Koo) ORCID logo https://orcid.org/0000-0001-5646-4072
최윤성(Choi, Yoon Seong)
최은창(Choi, Eun Chang)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146401
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