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US-localized diffuse optical tomography in breast cancer: comparison with pharmacokinetic parameters of DCE-MRI and with pathologic

 Min Jung Kim  ;  Min-Ying Su  ;  Hon J Yu  ;  Jeon-Hor Chen  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Ji Soo Choi 
 BMC CANCER, Vol.16(50) : 1-9, 2016 
Journal Title
Issue Date
Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Contrast Media/administration & dosage ; Estrogen Receptor alpha/metabolism ; Female ; Hemoglobins/isolation & purification ; Hemoglobins/pharmacokinetics* ; Humans ; Image Interpretation, Computer-Assisted ; Ki-67 Antigen/metabolism ; Magnetic Resonance Imaging/methods* ; Molecular Imaging/methods ; Neovascularization, Pathologic/diagnostic imaging ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Prognosis ; Radiography ; Receptor, ErbB-2/metabolism ; Receptors, Progesterone/metabolism ; Tomography, Optical/methods*
BACKGROUND: To correlate parameters of Ultrasonography-guided Diffuse optical tomography (US-DOT) with pharmacokinetic features of Dynamic contrast-enhanced (DCE)-MRI and pathologic markers of breast cancer. METHODS: Our institutional review board approved this retrospective study and waived the requirement for informed consent. Thirty seven breast cancer patients received US-DOT and DCE-MRI with less than two weeks in between imaging sessions. The maximal total hemoglobin concentration (THC) measured by US-DOT was correlated with DCE-MRI pharmacokinetic parameters, which included K(trans), k ep and signal enhancement ratio (SER). These imaging parameters were also correlated with the pathologic biomarkers of breast cancer. RESULTS: The parameters THC and SER showed marginal positive correlation (r = 0.303, p = 0.058). Tumors with high histological grade, negative ER, and higher Ki-67 expression ≥ 20% showed statistically higher THC values compared to their counterparts (p = 0.019, 0.041, and 0.023 respectively). Triple-negative (TN) breast cancers showed statistically higher K(trans) values than non-TN cancers (p = 0.048). CONCLUSION: THC obtained from US-DOT and K(trans) obtained from DCE-MRI were associated with biomarkers indicative of a higher aggressiveness in breast cancer. Although US-DOT and DCE-MRI both measured the vascular properties of breast cancer, parameters from the two imaging modalities showed a weak association presumably due to their different contrast mechanisms and depth sensitivities.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
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