323 276

Cited 2 times in

Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma

 Ja Seung Koo  ;  Ji Won Kim  ;  Jin Sook Yoon 
 YONSEI MEDICAL JOURNAL, Vol.57(2) : 482-489, 2016 
Journal Title
Issue Date
Adult ; Aged ; Autophagy* ; Beclin-1 ; Biomarkers, Tumor/metabolism ; Carcinoma, Adenoid Cystic/metabolism* ; Carcinoma, Adenoid Cystic/pathology ; Carrier Proteins ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lacrimal Apparatus/metabolism ; Lacrimal Apparatus/pathology ; Lacrimal Apparatus Diseases/metabolism* ; Lacrimal Apparatus Diseases/pathology ; Male ; Membrane Proteins ; Middle Aged ; Proto-Oncogene Proteins ; Reactive Oxygen Species/metabolism* ; Salivary Gland Neoplasms/metabolism ; Salivary Gland Neoplasms/pathology* ; Salivary Glands/pathology
Adenoid cystic carcinoma ; autophagy ; lacrimal gland ; reactive oxygen species ; salivary gland
PURPOSE: To investigate the difference of expression of autophagy and reactive oxygen species (ROS) related proteins in adenoid cystic carcinoma (ACC) of lacrimal gland in comparison with ACC of salivary gland. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue samples from patients pathologically diagnosed as lacrimal gland ACC (n=11) and salivary gland ACC (n=64) were used. Immunochemistry was used to measure expression of autophagy related proteins [beclin-1, light chain (LC) 3A, LC3B, p62, and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)] and ROS related proteins [catalase, thioredoxinreductase, glutathione S-transferasepi (GSTpi), thioredoxin interacting protein, and manganese superoxide dismutase (MnSOD)]. The prognostic factors related to disease-free and overall survival (OS) in lacrimal gland ACC by log-rank tests, were determined. RESULTS: GSTpi in stromal cells was more highly expressed in lacrimal gland ACC (p=0.006), however, MnSOD in epithelial cells was expressed more in salivary gland ACC (p=0.046). LC3B positivity and BNIP3 positivity in epithelial component were associated with shorter disease-free survival (both p=0.002), and LC3A positivity in stromal component was the factor related to shorter OS (p=0.005). CONCLUSION: This is the first study to demonstrate the expression of autophagy and ROS related proteins in lacrimal gland ACC in comparison with the salivary gland ACC, which would provide a basis for further study of autophagy and ROS mechanism as novel therapeutic targets in lacrimal gland ACC.
Files in This Item:
T201600264.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Ji Won(김지원)
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.